Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinase-Reference-Cited by-同舟云学术

Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinase

Published:2013-09 Issue:17 Volume:21 Page:5182-5187
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Sun Duoli,Bhanu Prasad Basvoju A.,Schuber Paul T.,Peng Zhenghong,Maxwell David S.,Martin Diana V.,Guo Liwei,Han Dongmei,Kurihara Hiroaki,Yang David J.,Gelovani Juri G.,Powis Garth,Bornmann William G.

Funder

Cancer Center support

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2. High Frequency of Mutations of the PIK3CA Gene in Human Cancers

3. The Phosphoinositide 3-Kinase Pathway

4. The PTEN–PI3K pathway: of feedbacks and cross-talks

5. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

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