Identification and optimization of a novel series of selective PIP5K inhibitors-Reference-Cited by-同舟云学术

Identification and optimization of a novel series of selective PIP5K inhibitors

Published:2022-01 Issue: Volume:54 Page:116557
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Andrews David M.,Cartic Sharon,Cosulich Sabina,Divecha Nullin,Faulder Paul,Flemington Vikki,Kern Oliver,Kettle Jason G.,MacDonald Ellen,McKelvie Jennifer,Pike Kurt G.,Roberts Bryan,Rowlinson Rachel,Smith James M.,Stockley Martin,Swarbrick Martin E.,Treinies Iris,Waring Michael J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. Nuclear phosphoinositides: their regulation and roles in nuclear functions;Fiume;Int J Mol Sci,2019

2. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha;Kisseleva;Mol Cell Biol,2005

3. Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis;Emoto;J Biol Chem,2005

4. Phosphoinositides: tiny lipids with giant impact on cell regulation;Balla;Physiol Rev,2013

5. The PI3K pathway in human disease;Fruman;Cell,2017

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of Novel Bicyclic Pyrazoles as Potent PIP5K1C Inhibitors;ACS Medicinal Chemistry Letters;2024-04-03

2. Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosis;2024-02-21

3. Lipid kinases PIP5Ks and PIP4Ks: potential drug targets for breast cancer;Frontiers in Oncology;2023-12-13

4. PIP kinases: A versatile family that demands further therapeutic attention;Advances in Biological Regulation;2023-01

5. Rational Design and Synthesis of D‐galactosyl Lysophospholipids as Selective Substrates and non‐ATP‐competitive Inhibitors of Phosphatidylinositol Phosphate Kinases;Chemistry – A European Journal;2022-11-24