Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile-Reference-Cited by-同舟云学术

Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile

Published:2018-07 Issue:12 Volume:26 Page:3261-3286
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Tokuhara Hidekazu^ORCID,Imaeda Yasuhiro,Fukase Yoshiyuki,Iwanaga Koichi,Taya Naohiro,Watanabe Koji,Kanagawa Ray,Matsuda Keisuke,Kajimoto Yumiko,Kusumoto Keiji,Kondo Mitsuyo,Snell Gyorgy,Behnke Craig A.,Kuroita Takanobu

Funder

National Institutes of Health, National Institute of General Medical Sciences

Howard Hughes Medical Institute

Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference41 articles.

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2. Maintenance of blood pressure by the renin–angiotensin system in normal man;MacGregor;Nature,1981

3. International Society of Hypertension Writing Group: 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension;World Health Organization;J Hypertens,2003