Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity-Reference-Cited by-同舟云学术

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

Published:2004-07 Issue:13 Volume:12 Page:3731-3742
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Ruchelman Alexander L,Kerrigan John E,Li Tsai-Kun,Zhou Nai,Liu Angela,Liu Leroy F,LaVoie Edmond J

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference72 articles.

1. Tumor Cell Death Induced by Topoisomerase-Targeting Drugs

2. DNA TOPOISOMERASES

3. DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

4. DNA Topoisomerases: Essential Enzymes and Lethal Targets

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