2-Aminomethylthieno[3,2- d ]pyrimidin-4(3 H )-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase-Reference-Cited by-同舟云学术

2-Aminomethylthieno[3,2- d ]pyrimidin-4(3 H )-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase

Published:2017-07 Issue:14 Volume:25 Page:3658-3670
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Kurasawa Osamu,Homma Misaki,Oguro Yuya,Miyazaki Tohru,Mori Kouji,Uchiyama Noriko,Iwai Kenichi,Ohashi Akihiro,Hara Hideto,Yoshida Sei^ORCID,Cho Nobuo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

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2. Cdc7 kinase complex: a key regulator in the initiation of DNA replication;Masai;J Cell Physiol,2002

3. Cdc7–Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation;Bonte;Neoplasia,2008

4. Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells;Montagnoli;Cancer Res,2004

5. Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones;Kurasawa;Bioorg Med Chem,2017

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