Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement-Reference-Cited by-同舟云学术

Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

Published:2019-11 Issue:22 Volume:27 Page:115083
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Gomes Juliana C.,Cianni Lorenzo,Ribeiro Jean,dos Reis Rocho Fernanda,da Costa Martins Silva Samelyn,Batista Pedro Henrique Jatai,Moraes Carolina Borsoi,Franco Caio Haddad,Freitas-Junior Lucio H.G.,Kenny Peter W.,Leitão Andrei,Burtoloso Antonio C.B.,de Vita Daniela,Montanari Carlos A.

Funder

FAPESP

CNPq

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference46 articles.

1. Nova tripanozomiaze humana. Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade morbida do homem;Chagas;Mem Inst Oswaldo Cruz,1909

2. Chagas disease;Rassi;Lancet,2010

3. Chagas disease: a Latin American health problem becoming a world health problem;Schmunis;Acta Trop,2010

4. Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro;Meirelles;Mol Biochem Parasitol,1992

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