Design of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities-Reference-Cited by-同舟云学术

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Design of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities

Published:2013-12 Issue:23 Volume:21 Page:7529-7538
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Fontenelle Clement Q.,Wang Zhong,Fossey Christine,Cailly Thomas,Linclau Bruno,Fabis Frederic

Funder

INTERREG IVa channel programme

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference49 articles.

1. A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930

2. Crosstalk between Rap1 and Rac regulates secretion of sAPPα

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1. Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation–Defluorination Pathway;Organic Letters;2020-03-25

2. Young Career Focus: Dr. Zhong Wang (University of Southampton, UK);SYNTHESIS-STUTTGART;2018

3. Lowering the p K a of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro;European Journal of Medicinal Chemistry;2015-08

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