Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53-Reference-Cited by-同舟云学术

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53

Published:2013-12 Issue:23 Volume:21 Page:7343-7356
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Abdel-Halim Mohammad,Keeton Adam B.,Gurpinar Evrim,Gary Bernard D.,Vogel Simon M.,Engel Matthias,Piazza Gary A.,Boeckler Frank M.,Hartmann Rolf W.,Abadi Ashraf H.

Funder

Alexander von Humboldt Foundation, Bonn, Germany

Group Linkage Research Program

MRC Laboratory for Molecular Biology, Cambridge/UK

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. p53, guardian of the genome

2. The ubiquitin-protein ligase activity of Hdm2 is inhibited by nucleic acids

3. Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination

4. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

5. Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

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