Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation-Reference-Cited by-同舟云学术

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Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation

Published:2019-02 Issue:4 Volume:27 Page:630-643
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Zhang Ting,Han Zhenglan,Shi Xuerui,Zhao Weidong,Wang Zilong,Zhang Run,Xu Biao,Zhang Mengna,Zhang Qinqin,Xiao Jian,Zhu Hanwen,Zheng Ting,Fang Quan

Funder

National Natural Science Foundation of China

Scientific Research Project of Universities in Gansu Province

Central Universities

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference58 articles.

1. Opioids, sensory systems and chronic pain;Stein;Eur J Pharmacol,2013

2. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain;Hanlon;Brain Res,2011

3. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance;Largent-Milnes;Br J Pharmacol,2010

4. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists;Yamamoto;J Med Chem,2009

5. A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic;Foran;Proc Natl Acad Sci U S A,2000

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Analgesic tolerance and cross-tolerance to the bifunctional opioid/neuropeptide FF receptors agonist EN-9 and μ-opioid receptor ligands at the supraspinal level in mice;Neuropeptides;2023-02

2. OFP011 Cyclic Peptide as a Multifunctional Agonist for Opioid/Neuropeptide FF Receptors with Improved Blood–Brain Barrier Penetration;ACS Chemical Neuroscience;2022-10-20

3. Fmoc solid-phase synthesis of RF9 optimization with mass spectrometry verification;Current Issues in Pharmacy and Medical Sciences;2022-07-01

4. VF-13, a chimeric peptide of VD-hemopressin(α) and neuropeptide VF, produces potent antinociception with reduced cannabinoid-related side effects;Neuropharmacology;2020-09

5. Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia;European Journal of Pharmacology;2020-08

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