The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design-Reference-Cited by-同舟云学术

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The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design

Published:2020-01 Issue:1 Volume:28 Page:115196
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Kyriakis Efthimios,Karra Aikaterini G.,Papaioannou Olga,Solovou Theodora,Skamnaki Vassiliki T.,Liggri Panagiota G.V.,Zographos Spyros E.,Szennyes Eszter,Bokor Éva,Kun Sándor,Psarra Anna-Maria G.,Somsák László,Leonidas Demetres D.

Funder

National Research Infrastructures

Competitiveness, Entrepreneurship and Innovation

Greece and the European Union

Hellenic State Scholarships Foundation

European Social Fund

General Secretariat for Research and Technology

Research and Innovation

National Research, Development and Innovation Office of Hungary

European Regional Development Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference63 articles.

1. Glycogen phosphorylase as a molecular target for type 2 diabetes therapy;Oikonomakos;Curr Protein Pept Sci,2002

2. Glycogen phosphorylase inhibition in type 2 diabetes therapy – a systematic evaluation of metabolic and functional effects in rat skeletal muscle;Baker;Diabetes,2005

3. Glycogen phosphorylase inhibition improves beta cell function;Nagy;Br J Pharmacol,2018

4. Current anti-diabetic agents and their molecular targets: a review;Kerru;Eur J Med Chem,2018

5. Glucose derived inhibitors of glycogen phosphorylase;Somsak;Compt Rend Chim,2011

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5. Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways;European Journal of Medicinal Chemistry Reports;2021-12

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