Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity-Reference-Cited by-同舟云学术

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: Discovery and computational modeling of a new series of ligands with nanomolar affinity

Published:2015-07 Issue:13 Volume:23 Page:3040-3058
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Anighoro Andrew^ORCID,Graziani Davide,Bettinelli Ilaria,Cilia Antonio,De Toma Carlo,Longhi Matteo,Mangiarotti Fabio,Menegon Sergio,Pirona Lorenza,Poggesi Elena,Riva Carlo,Rastelli Giulio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference49 articles.

1. PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

2. Glutamate Receptor Gating

3. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

4. Periplasmic binding protein structure and function

5. Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

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