The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain-Reference-Cited by-同舟云学术

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

Published:2019-01 Issue:1 Volume:27 Page:230-239
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Brown Alan D.,Bagal Sharan K.,Blackwell Paul,Blakemore David C.,Brown Bruce,Bungay Peter J.,Corless Martin,Crawforth James,Fengas David,Fenwick David R.,Gray Victoria,Kemp Mark,Klute Wolfgang,Malet Sanz Laia,Miller Duncan,Murata Yoshihisa,Payne C. Elizabeth,Skerratt Sarah,Stevens Edward B.,Warmus Joseph S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

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4. Faber CG, Lauria G, Merkies ISJ, et al. Gain-of-function Nav1.8 mutations in painful neuropathy. Proceedings of the National Academy of Sciences of the United States of America 2012, 109 (47), pp. 19444–19449, S19444/1-S19444/3.

5. SCN9A mutations in paroxysmal clinical study extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes;Fertleman;Neuron,2006

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