Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus-Reference-Cited by-同舟云学术

Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus

Published:2014-04 Issue:7 Volume:22 Page:2280-2293
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Park Kaapjoo,Lee Byoung Moon,Hyun Kwan Hoon,Lee Dong Hoon,Choi Hyun Ho,Kim Hyunmi,Chong Wonee,Kim Kyeong Bae,Nam Su Youn

Funder

Chungcheong Leading Industry Office for Medicine & Bio Projects

Ministry of Knowledge Economy

Republic of Korea

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference41 articles.

1. Microvascular and Macrovascular Complications of Diabetes

2. Mechanisms linking obesity to insulin resistance and type 2 diabetes

3. SGLT2 inhibitors enter crowded diabetes space

4. Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

5. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise

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3. Development of antidiabetic drugs from benzamide derivatives as glucokinase activator: A computational approach;Saudi Journal of Biological Sciences;2022-05

4. Design, Synthesis, Molecular Docking and In vitro Biological Evaluation of Benzamide Derivatives as Novel Glucokinase Activators;Current Enzyme Inhibition;2022-03

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