Inhibitory effect of propafenone on vortioxetine metabolism in vitro and in vivo

Author:

Xu Ren-ai,Luo Shunbin,Lin Qianmeng,Shao Yuanyuan,Chen Chaojie,Ye Xuemei

Publisher

Elsevier BV

Subject

General Chemical Engineering,General Chemistry

Reference26 articles.

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2. Safety, tolerability, and efficacy of vortioxetine (Lu AA21004) in major depressive disorder: results of an open-label, flexible-dose, 52-week extension study;Alam;Int. Clin. Psychopharmacol.,2014

3. Population pharmacokinetic meta-analysis of vortioxetine in healthy individuals;Areberg;Basic Clin. Pharmacol. Toxicol.,2014

4. Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites;Botsch;Mol. Pharmacol.,1993

5. Vortioxetine: Clinical Pharmacokinetics and Drug Interactions;Chen;Clin. Pharmacokinet.,2018

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