Simultaneous assay of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma using normal-phase liquid chromatography–tandem mass spectrometry with a silica column and an aqueous organic mobile phase
Author:
Publisher
Elsevier BV
Subject
General Chemistry
Reference44 articles.
1. Morphine Pharmacokinetics and Metabolism in Humans
2. Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes
3. the apparent affinity of morphine-3-glucuronide at μ1-opioid receptors results from morphine contamination: demonstration using HPLC and radioligand binding
4. Morphine-3-glucuronide: evidence to support its putative role in the development of tolerance to the antinociceptive effects of morphine in the rat
5. Pharmacokinetics of morphine and its glucuronides after intravenous infusion of morphine and morphine-6-glucuronide in healthy volunteers*
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1. Development and validation of a UPLC-MS/MS method with a broad linear dynamic range for the quantification of morphine, morphine-3-glucuronide and morphine-6-glucuronide in mouse plasma and tissue homogenates;Journal of Chromatography B;2021-03
2. Bioanalysis of small and large molecule drugs, metabolites, and biomarkers by LC-MS;Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters;2020
3. Bioanalytical challenges and strategies for accurately measuring acyl glucuronide metabolites in biological fluids;Biomedical Chromatography;2019-08-20
4. Discovery, identification and mitigation of isobaric sulfate metabolite interference to a phosphate prodrug in LC–MS/MS bioanalysis: Critical role of method development in ensuring assay quality;Journal of Pharmaceutical and Biomedical Analysis;2018-06
5. Simultaneous determination of morphine-6-d -glucuronide, morphine-3-d -glucuronide and morphine in human plasma and urine by ultra-performance liquid chromatography-tandem mass spectrometry: Application to M6G injection pharmacokinetic study;Biomedical Chromatography;2017-09-15
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