Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a

Author:

Eliwa Duaa,Albadry Mohamed A.,Ibrahim Abdel-Rahim S.ORCID,Kabbash Amal,Meepagala Kumudini,Khan Ikhlas A.,El-Aasr Mona,Ross Samir A.

Funder

USDA Agricultural Research Service

Publisher

Elsevier BV

Subject

Horticulture,Plant Science,Molecular Biology,General Medicine,Biochemistry

Reference15 articles.

1. Cross-linking of protein crystals as an aid in the generation of binary protein-ligand crystal complexes, exemplified by the human PDE10a-papaverine structure;Andersen;Acta Crystallogr.,2009

2. Metabolism of papaverine. I. Identification of metabolites in rat bile;Belpaire;Xenobiotica,1975

3. The protein Data Bank;Berman;Nucleic Acids Res.,2000

4. Opium Alkaloids VII. Isolation of a new benzylisoquinoline alkaloid. Synthesis and NMR Studies of papaveroline trimethyl ethers;Brochmann-Hanssen;J. Pharmaceut. Sci.,1968

5. A novel role of cyclic nucleotide phosphodiesterase 10A in pathological cardiac remodeling and dysfunction;Chen;Circulation,2020

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