Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity

Author:

Qing Zhixing,Shi Yao,Han Lida,Li Pengkun,Zha Ziou,Liu Chang,Liu Xiubin,Huang Peng,Liu Yisong,Tang Qi,Zeng Kewu,Zeng Jianguo,Zhou Yuan

Publisher

Elsevier BV

Subject

Horticulture,Plant Science,Molecular Biology,General Medicine,Biochemistry

Reference23 articles.

1. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice;Blaskovich;Cancer Res.,2003

2. Cucurbitacins and cucurbitane glycosides: structures and biological activities;Chen;Nat. Prod. Rep.,2005

3. Cucurbitacin B induces apoptosis and S phase cell cycle arrestin BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration;Chan;Cancer Lett.,2010

4. Cucurbitacins: a systematic review of the phytochemistry and anticancer activity;Cai;Am. J. Chin. Med.,2015

5. Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo;Deng;Cell Death Dis.,2016

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