A feed enrichment strategy targeting the tricarboxylic acid cycle for increasing monoclonal antibody production and alleviating ammonia accumulation in Chinese hamster ovary cell culture-Reference-Cited by-同舟云学术

A feed enrichment strategy targeting the tricarboxylic acid cycle for increasing monoclonal antibody production and alleviating ammonia accumulation in Chinese hamster ovary cell culture

Published:2023-03 Issue: Volume:192 Page:108836
ISSN:1369-703X
Container-title:Biochemical Engineering Journal
language:en
Short-container-title:Biochemical Engineering Journal

Author:

Saldanha Marianne,Padhye Krutika,Warke Vishal G.,Dandekar Prajakta^ORCID,Jain Ratnesh^ORCID

Publisher

Elsevier BV

Subject

Biomedical Engineering,Environmental Engineering,Bioengineering,Biotechnology

Reference23 articles.

1. Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture;Templeton;Biotechnol. Bioeng.,2013

2. Metabolic analysis of antibody producing CHO cells in fed-batch production;Dean;Biotechnol. Bioeng.,2013

3. Titer of trastuzumab produced by a Chinese hamster ovary cell line is associated with tricarboxylic acid cycle activity rather than lactate metabolism;Ishii;J. Biosci. Bioeng.,2015

4. Leaks in the tricarboxylic acid (TCA) cycle;Engelking,2015

5. Responses of CHO-DHFR cells to ratio of asparagine to glutamine in feed media: cell growth, antibody production, metabolic waste, glutamate, and energy metabolism;xiang Zhang,2016

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