Minimally-disruptive method to estimate the volumetric oxygen mass transfer coefficient (kLa) for recombinant Escherichia coli fermentations

Author:

Mercado Elliot,Mbiki Sarah,Harcum Sarah W.,Gilmore Jordon A.S.

Funder

National Science Foundation

Publisher

Elsevier BV

Subject

Biomedical Engineering,Environmental Engineering,Bioengineering,Biotechnology

Reference42 articles.

1. Biopharmaceutical benchmarks 2018;Walsh;Nat. Biotechnol.,2018

2. Recombinant pharmaceuticals from microbial cells: a 2015 update;Sanchez-Garcia;Microb. Cell Fact.,2016

3. Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells;Berlec;J. Ind. Microbiol. Biotechnol.,2013

4. Oxygen uptake rate soft-sensing via dynamic kla computation: cell volume and metabolic transition prediction in mammalian bioprocesses;Pappenreiter;Front. Bioeng. Biotechnol.,2019

5. Oxygen mass transfer in biopharmaceutical processes: numerical and experimental approaches;Seidel;Chem. Ing. Tech.,2021

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