Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system

Effect of long-term vigabatrin therapy on GABA and other amino acid concentrations in the central nervous system — a case study

Published:1993-12 Issue:3 Volume:16 Page:241-243
ISSN:0920-1211
Container-title:Epilepsy Research
language:en
Short-container-title:Epilepsy Research

Author:

Ben-Menachem Elinor,Hamberger Anders,Mumford John

Publisher

Elsevier BV

Subject

Neurology (clinical),Neurology

Reference10 articles.

1. Changes in CSF parameters and seizure control with every third day, every other day and daily dosing of gamma-vinyl GABA;Ben-Menachem;Epilepsia,1986

2. The effect of different vigabatrin treatment regimens on CSF biochemistry and seizure control in epileptic patients;Ben-Menachem;Br. J. Clin. Pharmacol.,1989

3. Effect of long term vigabatrin therapy on selected CSF neurotrans-mitter concentrations;Ben-Menachem;J. Child Neurol.,1991

4. Acute effects of sodium valproate and gamma-vinyl GABA on regional amino acid metabolism in the rat brain;Chapman;Neurochem. Res.,1982

5. Concentration gradients of free and total gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid);Grove;Life Sci.,1981

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1. Mechanism of action of vigabatrin: correcting misperceptions;Acta Neurologica Scandinavica;2011-11-08

2. GABAA autoreceptors enhance GABA release from human neocortex: towards a mechanism for high-frequency stimulation (HFS) in brain?;Naunyn-Schmiedeberg's Archives of Pharmacology;2009-03-19

3. Vigabatrin extracellular pharmacokinetics and concurrent γ-aminobutyric acid neurotransmitter effects in rat frontal cortex and hippocampus using microdialysis;Epilepsia;2009-01-27

4. SEIZURE DISORDERS;Pharmacology and Therapeutics;2009

5. Novel Mechanisms of Action of Three Antiepileptic Drugs, Vigabatrin, Tiagabine, and Topiramate;Neurochemical Research;2003-02