Mitochondrial targeting sequences why ‘non-amphiphilic’ peptides may still be amphiphilic
Author:
Publisher
Wiley
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1016/0014-5793(88)81257-2/fullpdf
Reference10 articles.
1. A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers.
2. Mitochondrial targeting sequences may form amphiphilic helices.
3. The ornithine transcarbamylase leader peptide directs mitochondrial import through both its midportion structure and net positive charge.
4. Artificial mitochondrial presequences.
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