2,4-Diamino-N10-methylpteroic acid (DAMPA) crystalluria in a patient with osteosarcoma treated with carboxypeptidase-G2 rescue after high-dose methotrexate-induced nephrotoxicity

Author:

Berga Francisco,Luna Pablo,Martorell Clara,Rey Juan,Gomila Isabel,Gimenez Sandra,Costa-Bauza Antonia,Elorza Miguel Ángel,Sánchez Iolanda,Grases Félix,Barceló Bernardino

Funder

Servicio de Ocupación de las Islas Baleares

European Social Fund

Ministerio de Empleo y Seguridad Social

University of the Balearic Islands

Publisher

Elsevier BV

Subject

Biochemistry (medical),Clinical Biochemistry,Biochemistry,General Medicine

Reference26 articles.

1. Preventing and managing toxicities of high-dose methotrexate;Howard;Oncologist,2016

2. Understanding and managing methotrexate nephrotoxicity;Widemann;Oncologist,2006

3. Pharmacokinetics and metabolism of the methotrexate metabolite 2,4-diamino-N(10)-methylpteroic acid;Widemann;J. Pharmacol. Exp. Ther.,2000

4. Presence of 2,4-diamino-N10-methylpteroic acid after high-dose methotrexate;Donehower;Clin. Pharmacol. Ther.,1979

5. 7-Hydroxymethotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high dose methotrexate;Jacobs;J. Clin. Invest.,1976

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