Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1

Author:

Moyer Benjamin J.,Rojas Itzel Y.,Kerley-Hamilton Joanna S.,Hazlett Haley F.,Nemani Krishnamurthy V.,Trask Heidi W.,West Rachel J.,Lupien Leslie E.,Collins Alan J.,Ringelberg Carol S.,Gimi Barjor,Kinlaw William B.,Tomlinson Craig R.

Funder

NIH/NCRR

NIH/NIGMS

Norris Cotton Cancer Center Prouty

Department of Medicine Research

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference88 articles.

1. Chemical toxins: a hypothesis to explain the global obesity Epidemic;Baillie-Hamilton;The J. Altern. Complement. Med.,2002

2. Aryl hydrocarbon receptor control of a disease tolerance defence pathway;Bessede;Nature,2014

3. Chronic immune activation underlies morbid obesity: is IDO a key player?;Brandacher;Curr. Drug Metab.,2007

4. Health and mortality consequences of abdominal obesity: evidence from the AusDiab study;Cameron;Med. J. Aust.,2009

5. Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity;Casper;Mol. Pharmacol.,1999

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