Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol

Author:

Salazar Keith D.,Brinkerhoff Christopher J.,Lee Janice S.,Chiu Weihsueh A.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference40 articles.

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2. Physiological modelling of organic compounds;Andersen;Ann. Occup. Hyg.,1991

3. Development and use of PBPK modeling and the impact of metabolism on variability in dose metrics for the risk assessment of methyl tertiary butyl ether (MTBE);Blancato;J. Environ. Prot. Sci.,2007

4. Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats;Borghoff;Fundam. Appl. Toxicol.,1996

5. alpha2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats;Borghoff;Toxicol. Sci.,2001

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