In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat

Author:

Beverly Brandiese E.J.,Furr Johnathan R.,Lambright Christy S.,Wilson Vickie S.,McIntyre Barry S.,Foster Paul M.D.,Travlos Greg,Earl Gray L.

Funder

USEPA

Oak Ridge Institute for Science and Education

National Institute of Environmental Health Sciences

National Institutes of Health

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference28 articles.

1. A preliminary study on the reproductive toxicity of statins in rats;Aditya;Int. J. Res. Biosci.,2014

2. Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate;Barlow;Toxicol. Pathol.,2003

3. Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat;Beverly;Toxicol. Sci.,2014

4. Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate;Carruthers;Birth Defects Res. B Dev. Reprod Toxicol.,2005

5. Developmental toxicity of the hmg-coa reductase inhibitor, atorvastatin, in rats and rabbits;Dostal;Teratology,1994

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