Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy

Author:

Wu Kai Connie,Adedeji Adeyemi O.,Zabka Tanja S.,Hosseini Iraj,Kenkre Radhika,Getz Jennifer A.,Nguyen Tien,Decalf Jérémie,Bainbridge Travis W.,Chilton Jennifer A.,Moussion Christine C.,Rao Gautham K.ORCID

Funder

Genentech

Publisher

Elsevier BV

Reference30 articles.

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2. Abstract 9589: A phase II randomized study of CDX-1401, a dendritic cell targeting NY-ESO-1 vaccine, in patients with malignant melanoma pre-treated with recombinant CDX-301, a recombinant human Flt3 ligand;Bhardwaj;J. Clin. Oncol.,2016

3. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting Cancer immune control;Bottcher;Cell,2018

4. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity;Broz;Cancer Cell,2014

5. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells;Cheng;Cell,2021

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