Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach

Author:

Chiu Weihsueh A.,Okino Miles S.,Evans Marina V.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference131 articles.

1. ATSDR, 1997. Toxicological profile for trichloroethylene. Agency for Toxic Substance and Disease Registry. http://www.atsdr.cdc.gov/toxprofiles/tp19.pdf.

2. ATSDR, 2003. ToxFAQs for trichloroethylene. Agency for Toxic Substance and Disease Registry. http://www.atsdr.cdc.gov/tfacts19.pdf.

3. A physiologically based pharmacokinetic model for trichloroethylene and its metabolites, chloral hydrate, trichloroacetate, dichloroacetate, trichloroethanol, and trichloroethanol glucuronide in B6C3F1 mice;Abbas;Toxicol. Appl. Pharmacol.,1997

4. Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice;Abbas;Drug Metab. Dispos.,1996

5. Determination of kinetic rate constants for chloral hydrate, trichloroethanol, trichloroacetic acid, and dichloroacetic acid—a physiologically based modeling approach;Abbas;Toxicologist,1997

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