Pirfenidone ameliorates ANIT-induced cholestatic liver injury via modulation of FXR, NF-кB/TNF-α, and Wnt/GSK-3β/β-catenin signaling pathways

Author:

Abdulaal Wesam H.,Omar Ulfat M.,Zeyadi Mustafa,El-Agamy Dina S.,Alhakamy Nabil A.,Ibrahim Sabrin R.M.,Almalki Naif A.R.,Asfour Hani Z.,Al-Rabia Mohammed W.,Mohamed Gamal A.,Elshal Mahmoud

Funder

Deanship of Scientific Research, King Saud University

King Abdulaziz University

Publisher

Elsevier BV

Reference65 articles.

1. Pirfenidone as a novel cardiac protective treatment;Aimo;Heart Fail. Rev.,2022

2. Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine;Arumugam;Clin. Exp. Pharmacol. Physiol.,2002

3. Inhibiting Wnt signaling reduces cholestatic injury by disrupting the inflammatory axis;Ayers;Cell. Mol. Gastroenterol. Hepatol.,2023

4. Paeoniflorin protects against ANIT-induced cholestatic liver injury in rats via the activation of SIRT1-FXR signaling pathway;Chen;Evid. Based Complement. Alternat. Med.,2021

5. Role of β-catenin in development of bile ducts;Cordi;Differentiation,2016

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