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Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?

  • Published:2018-05 Issue: Volume:346 Page:45-57
  • ISSN:0041-008X
  • Container-title:Toxicology and Applied Pharmacology
  • language:en
  • Short-container-title:Toxicology and Applied Pharmacology

Author:

Kreir M.ORCID,Van Deuren B.,Versweyveld S.,De Bondt A.,Van den Wyngaert I.,Van der Linde H.,Lu H.R.,Teuns G.,Gallacher D.J.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference68 articles.

1. Seizure liability assessments using the hippocampal tissue slice: comparison of non-clinical species;Accardi;J. Pharmacol. Toxicol. Methods,2017

2. Aconitine inhibits epileptiform activity in rat hippocampal slices;Ameri;Naunyn Schmiedeberg's Arch. Pharmacol.,1996

3. Safety pharmacology investigations on the nervous system: an industry survey;Authier;J. Pharmacol. Toxicol. Methods,2016

4. Models of drug-induced epileptiform synchronization in vitro;Avoli;J. Neurosci. Methods,2016

5. Culturing Nerve Cells;Banker,1998
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