The effect of shikonin on the metabolism of lapatinib in vitro, and in vivo
Author:
Publisher
Elsevier BV
Subject
Pharmacology,Toxicology
Reference24 articles.
1. Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate;Barbara;Drug Metab. Dispos.,2013
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3. An examination of IC50 and IC50-shift experiments in assessing time-dependent inhibition of CYP3A4, CYP2D6 and CYP2C9 in human liver microsomes;Berry;Drug Metab. Lett.,2008
4. Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas;Burris;J. Clin. Oncol.,2005
5. Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent;Chen;Eur. J. Pharm. Sci.,2013
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