HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling

Author:

Chen I-Hua,Shih Hsin-Chu,Hsieh Pei-Wen,Chang Fang-Rong,Wu Yang-Chang,Wu Chin-Chung

Funder

National Science Council of Taiwan

Excellence for Cancer Research Center Grant

Ministry of Health and Welfare, Executive Yuan, Taipei, Taiwan

Health and Welfare Surcharge of Tobacco Products

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference70 articles.

1. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells;Arboleda;Cancer Res.,2003

2. Spheroids and cell survival;Bates;Crit. Rev. Oncol. Hematol.,2000

3. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells;Berezovskaya;Cancer Res.,2005

4. Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion;Bharadwaj;Oncogene,2005

5. Extracellular matrix and integrin signalling: the shape of things to come;Boudreau;Biochem. J.,1999

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