Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat-Reference-Cited by-同舟云学术

Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat

Published:2021-07 Issue: Volume:423 Page:115578
ISSN:0041-008X
Container-title:Toxicology and Applied Pharmacology
language:en
Short-container-title:Toxicology and Applied Pharmacology

Author:

Werner Jonathan A.,Davies Rhian,Wahlstrom Jan,Dahal Upendra P.,Jiang Min,Stauber Jonathan,David Benjamin,Siska William,Thomas Barbara,Ishida Katsu,Humphreys W. Griffith,Lipford J. Russell,Monticello Thomas M.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference38 articles.

1. AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium;AACR;Cancer Discov.,2017

2. Formation and toxicity of anesthetic degradation products;Anders;Annu. Rev. Pharmacol. Toxicol.,2005

3. Approaches to mitigate the risk of serious adverse reactions in covalent drug design;Baillie;Expert Opin. Drug Discovery,2020

4. ras genes;Barbacid;Annu. Rev. Biochem.,1987

5. Nephrotoxicity and renal pathophysiology: a contemporary perspective;Barnett;Toxicol. Sci.,2018

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Validated LC-MS/MS method for simultaneous quantification of KRASG12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study;Journal of Pharmaceutical and Biomedical Analysis;2023-10

2. KRAS Inhibitors;Molecules Engineered Against Oncogenic Proteins and Cancer;2023-09-08

3. Drug development of covalent inhibitors;Overcoming Obstacles in Drug Discovery and Development;2023

4. Green Chemistry Method Based on Native Fluorescence for Estimation of Recently Approved Anti-neoplastic Drug Sotorasib;Analytical Chemistry Letters;2022-11-02

5. Validation of an LC–MS/MS method for the determination of sotorasib, a KRAS^G12C inhibitor, in human plasma;Bioanalysis;2022-10