Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

Author:

Kashimshetty Rohini,Desai Varsha G.,Kale Vijay M.,Lee Taewon,Moland Carrie L.,Branham William S.,New Lee S.,Chan Eric C.Y.,Younis Husam,Boelsterli Urs A.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference50 articles.

1. Flutamide-induced hepatic dysfunction in relation to steady-state plasma concentrations of flutamide and its metabolites;Aizawa;Mol. Cell. Biochem.,2003

2. The heterozygous Sod2+/− mouse: modeling the mitochondrial role in drug toxicity;Boelsterli;Drug Discov. Today,2008

3. Development of animal models of drug-induced mitochondrial toxicity;Boelsterli,2008

4. Mitochondrial abnormalities—a link to idiosyncratic drug hepatotoxicity?;Boelsterli;Toxicol. Appl. Pharmacol,2007

5. Bioactivation and hepatotoxicity of nitroaromatic drugs;Boelsterli;Curr. Drug Metab.,2006

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