Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

Author:

Kelley Robin Kate,Ueno Makoto,Yoo Changhoon,Finn Richard S,Furuse Junji,Ren Zhenggang,Yau Thomas,Klümpen Heinz-Josef,Chan Stephen L,Ozaka Masato,Verslype Chris,Bouattour Mohamed,Park Joon Oh,Barajas Olga,Pelzer Uwe,Valle Juan W,Yu Li,Malhotra Usha,Siegel Abby B,Edeline Julien,Vogel Arndt,Akce Mehmet,Ales Diaz Inmaculada,Alves Gustavo,Anand Sumitra,Arslan Cagatay,Asselah Jamil,Assenat Eric,Aubin Francine,Bai Li-Yuan,Bai Yuxian,Barajas Olga,Bates Susan,Begbie Stephen,Ben-Aharon Irit,Beri Nina,Berres Marie-Luise,Blanc Jean-Frederic,Borbath Ivan,Bordonaro Robert,Bouattour Mohamed,Brandi Giovanni,Burgoyne Adam,Butthongkomvong Kritiya,Camandaroba Marcos,Cao Ke,Carballido Marcela,Chan Stephan Lam,Chen Jen-Shi,Chen Ming-Huang,Chen Xiaoming,Cheng Ashley,Chiu Tai-Jan,Choi Hye Jin,Chon Hong Jae,Collignon Joelle,Cubillo Gracian Antonio,Davis Sarah,de Carvalho Ricardo Saraiva,de Groot D.J.A.,Demols Anne,De Vos Judith,Diab Maria,Easaw Jacob,Eatock Martin,Edeline Julien,Elias Rawad,Eskens Fredericus,Falcone Alfredo,Fernandez Plinio,Finn Richard,Franke Fabio,Furukawa Masayuki,Furuse Junji,Gbolahan Olumide,Geboes Karen,Geneser Keri-Lee,Geng Zhimin,Geva Ravit,Gillmore Roopinder,Goetze Thorsten,Gou Hongfeng,Grasselli Julieta,Gu Shanzhi,Gumus Mahmut,Haj Mohammad Nadia,Hao Chunyi,Harputluoglu Hakan,Hatoum Hassan,Heinemann Volker,Ho Wang Kwong,Hsu Chiun,Hubert Ayala,Hwang Juneul,Inanc Mevlude,Iseas Soledad,Jeyasingam Vaishnavi,Jimenez Fonseca Paula,Joubert Warren,Juengsamarn Jitlada,Kaen Diego,Kanai Masashi,Kasper-Virchow Stefan,Kazemi Ghazaleh,Kelleher Fergal,Kelley Robin,Kim Jin Won,Kim Jong Gwang,Kinupe Abrahao Ana Beatriz,Klumpen Heinz,Kochenderfer Mark,Kose Fatih,Lam Ho Ching,Lee Choong-kun,Lee Hyun Woo,Lee Margaret,Lee Myung Ah,Lee Wai Man Sarah,Le Sourd Samuel,Li Dongliang,Li Wei,Liang Houjie,Liang Tingbo,Lim Chun Sen,Lingerfelt Brian,Lopez Charles,Low John,Macarulla Mercade Teresa,Malka David,Mao Yimin,Masi Gianluca,McCune Steven,McDermott Ray,McWhirter Elaine,Mendez Guillermo,Milella Michele,Mizuno Nobumasa,Mizutani Tomonori,Moniz Camila,Morales Luisa,Munoz Martin Andres Jesús,Nervi Bruno,Ngamphaiboon Nuttapong,Oh Sang Cheul,Oksuzoglu Berna,Outlaw Darryl,Ozaka Masato,Ozguroglu Mustafa,Ozyilkan Ozgur,Painemal Claudio,Pan Yueyin,Park Joon Oh,Pelzer Uwe,Peng Chuang,Petorin Caroline,Pezet Denis,Power Derek,Qin Shukui,Ren Zhenggang,Roohullah Aflah,Ryu Hyewon,Salman Pamela,Sasaki Mitsuhito,Sasidharan Rita,Satoh Taroh,Schulze Kornelius,Scott-Brown Martin,Segovia Ruben,Seufferlein Thomas,Siena Salvatore,Sinapi Isabelle,Smolenschi Cristina,Song Tianqiang,Sookprasert Aumkhae,Soparattanapaisarn Nopadol,Starling Naureen,Stein Stacey,Stemmer Salomon,Su Haichuan,Sugimoto Rie,Suksombooncharoen Thatthan,Tam Vincent,Tan Ai Lian,Tan Chih Kiang,Tanasanvimon Suebpong,Tonini Giuseppe,Tortora Giampaolo,Tsuji Akihito,Ueno Makoto,Uribe Rodrigo,Venerito Marino,Verdaguer Mata Helena,Verslype Chris,Victorino Ana Paula,Vogel Arndt,Wade James,Waldschmidt Dirk Thomas,Wang Lu,Wan Isahk Wan Zamaniah,Wasan Harpeet,Weschenfelder Rui,Wong Chun Yin,Wong Yoke Fui,Yalcin Suayib,Yanez Weber Patricio,Yang Xuezhong,Yasui Hisateru,Yau Thomas,Yazici Ozan,Yen Chia-Jui,Ying Jieer,Yoo Changhoon,Yu Wenchang,Zhao Haitao

Funder

Merck Sharp and Dohme

Publisher

Elsevier BV

Subject

General Medicine

Reference30 articles.

1. Biliary tract cancer;Valle;Lancet,2021

2. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a systematic review and meta-analysis;Clements;J Hepatol,2020

3. Whole-genome and epigenomic landscapes of etiologically distinct subtypes of cholangiocarcinoma;Jusakul;Cancer Discov,2017

4. Identification of four immune subtypes characterized by distinct composition and functions of tumor microenvironment in intrahepatic cholangiocarcinoma;Job;Hepatology,2020

5. Clinical, genomic, and transcriptomic data profiling of biliary tract cancer reveals subtype-specific immune signatures;Mody;JCO Precis Oncol,2022

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