Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Author:

Thomalla Götz,Boutitie Florent,Ma Henry,Koga Masatoshi,Ringleb Peter,Schwamm Lee H,Wu Ona,Bendszus Martin,Bladin Christopher F,Campbell Bruce C V,Cheng Bastian,Churilov Leonid,Ebinger Martin,Endres Matthias,Fiebach Jochen B,Fukuda-Doi Mayumi,Inoue Manabu,Kleinig Timothy J,Latour Lawrence L,Lemmens Robin,Levi Christopher R,Leys Didier,Miwa Kaori,Molina Carlos A,Muir Keith W,Nighoghossian Norbert,Parsons Mark W,Pedraza Salvador,Schellinger Peter D,Schwab Stefan,Simonsen Claus Z,Song Shlee S,Thijs Vincent,Toni Danilo,Hsu Chung Y,Wahlgren Nils,Yamamoto Haruko,Yassi Nawaf,Yoshimura Sohei,Warach Steven,Hacke Werner,Toyoda Kazunori,Donnan Geoffrey A,Davis Stephen M,Gerloff Christian,Acosta Boris Raul,Aegidius Karen,Albiker Christian,Alegiani Anna,Almendrote Miriam,Alonso Angelika,Althaus Katharina,Amarenco Pierre,Amiri Hemasse,Anders Bettina,Aniculaesei Adriana,Appleton Jason,Arenillas Juan,Back Christina,Bähr Christian,Bardutzky Jürgen,Baronnet-Chauvet Flore,Bathe-Peters Rouven,Bayer-Karpinska Anna,Becerra Juan L.,Beck Christoph,Belchí Guillamon Olga,Benoit Amandine,Berhoune Nadia,Bindila Daniela,Birchenall Julia,Blanc-Lasserre Karine,Blanco Gonzales Miguel,Bobinger Tobias,Bodechtel Ulf,Bodiguel Eric,Bojaryn Urszula,Bonnet Louise,Bouamra Benjamin,Bourgeois Paul,Boutitie Florent,Breuer Lorenz,Breynaert Ludovic,Broughton David,Brouns Raf,Brugirard Sébastian,Bruneel Bart,Buggle Florian,Cakmak Serkan,Calleja Ana,Calvet David,Carrera David,Chen Hsin-Chieh,Cheng Bastian,Cheripelli Bharath,Cho Tae-Hee,Choe Chi-un,Choy Lillian,Christensen Hanne,Ciatipis Mareva,Cloud Geoffrey,Cogez Julien,Cortijo Elisa,Crozier Sophie,Damgaard Dorte,Dani Krishna,De Coene Beatrijs,De Hollander Isabel,De Keyser Jacques,De Klippel Nina,De Maeseneire Charlotte,De Smedt Ann,del Mar Castellanos Rodrigo Maria,Deltour Sandrine,Demeestere Jelle,Derex Laurent,Desfontaines Philippe,Dittrich Ralf,Dixit Anand,Dobbels Laurens,Domigo Valérie,Dorado Laura,Druart Charlotte,Dupont Kristina Hougaard,Dusart Anne,Dziewas Rainer,Ebinger Martin,Ebner Matthias,Edjali-Goujon Myriam,Eisele Philipp,El Tawil Salwa,Elhfnawy Ahmed,Endres Matthias,Etexberria Ana,Evans Nicholas,Fandler Simon,Fazekas Franz,Felix Sandra,Fiebach Jochen B.,Fiehler Jens,Filipov Alexandra,Filipski Katharina,Fleischmann Robert,Foerch Christian,Ford Ian,Gaenslen Alexandra,Galinovic Ivana,Gancedo Elena Meseguer,Ganeshan Ramanan,García Esperón Carlos,Garrido Alicia,Gattringer Thomas,Geraghty Olivia,Geran Rohat,Gerloff Christian,Gerner Stefan,Godon-Hardy Sylvie,Göhler Jos,Golsari Amir,Gomis Meritxell,Gorriz David,Gramse Verena,Grau Laia,Griebe Martin,Guerrero Cristina,Guerzoglu Damla,Guettier Sophie,Guiraud Vincent,Gumbinger Christoph,Gunreben Ignaz,Haertig Florian,Hametner Christian,Hanseeuw Bernard,Hansen Andreas,Hansen Jakob,Harbo Thomas,Harloff Andreas,Harmel Peter,Häusler Karl Georg,Heinen Florian,Held Valentin,Hellwig Simon,Hemelsoet Dimitri,Hennerici Michael,Herm Juliane,Hermans Sylvia,Hernández María,Hervas Vicente Jose,Hjort Niels,Hobeanu Cristina,Hobohm Carsten,Höfner Elmar,Hohenbichler Katharina,Hommel Marc,Hoppe Julia,Hornberger Eva,Hoyer Carolin,Huang Xuya,Ipsen Nils,Isern Irina,Ispierto Lourdes,Iversen Helle,Jeppesen Lise,Jimenez Marta,Jungehülsing Jan,Jüttler Eric,Kalladka Dheeraj,Kallmünzer Bernd,Kar Arindam,Kellert Lars,Kemmling André,Kessler Tobias,Khan Usman,Klein Matthias,Kleinschnitz Christoph,Klockziem Matti,Knops Michael,Koehler Luzie,Koehrmann Martin,Kohlfürst Heinz,Kollmar Rainer,Kraft Peter,Krause Thomas,Kristensen Bo,Kröber Jan M.,Kurka Natalia,Ladoux Alexandre,Laloux Patrice,Lamy Catherine,Landrault Emmanuelle,Lauer Arne,Lebely Claire,Leempoel Jonathan,Lees Kennedy,Leger Anne,Legrand Laurence,Lemmens Robin,Li Lin,Löbbe Anna-Mareike,London Frederic,Lopez-cancio Elena,Lorenz Matthias,Louw Stephen,Lovelock Caroline,Lozano Sánchez Manuel,Lucente Giuseppe,Lückl Janos,Luna Alain,Macha Kosmas,Machet Alexandre,Mackenrodt Daniel,Madzar Dominik,Majoie Charles,Männer Anika,Maqueda Vicky,Marstrand Jacob,Martinez Alicia,Marzina Annika,Mechthouff Laura,Meden Per,Meersman Guy,Meier Julia,Mellerio Charles,Menn Oliver,Meyer Nadja,Michalski Dominik,Michels Peter,Michelsen Lene,Millán Torne Monica,Minnerup Jens,Modrau Boris,Moeller Sebastian,Møller Anette,Morel Nathalie,Moreton Fiona,Morin Ludovic,Moulin Thierry,Moynihan Barry,Mueller Anne K.,Muir Keith W.,Mulero Patricia,Mundiyanapurath Sibu,Mutzenbach Johannes,Nagel Simon,Naggara Oliver,Nallasivan Arumugam,Navalpotro Irene,Nave Alexander H.,Nederkoorn Paul,Neeb Lars,Neugebauer Hermann,Neumann-Haefelin Tobias,Nighoghossian Norbert,Oberndorfer Stefan,Opherk Christian,Oppel Lorenz,Oppenheim Catherine,Orthgieß Johannes,Ostergaard Leif,Paindeville Perrine,Palomeras Ernest,Panitz Verena,Patel Bhavni,Peeters Andre,Peeters Dirk,Pellisé Anna,Pelz Johann,Pereira Anthony,Pérez de la Ossa Natalia,Perry Richard,Petraza Salvador,Peysson Stéphane,Pfeilschifter Waltraud,Pichler Alexander,Pierskalla Alexandra,Pledl Hans-Werner,Poli Sven,Pomrehn Katrin,Poulsen Marika,Prats Luis,Presas Silvia,Prohaska Elisabeth,Puetz Volker,Puig Josep,Puig Alcántara Josep,Purrucker Jan,Quenardelle Veronique,Ramachandran Sankaranarayanan,Raphaelle Soulliard,Raposo Nicolas,Reiff Tilman,Remmers Michel,Renou Pauline,Ribitsch Martin,Richter Hardy,Ringleb Peter,Ritter Martin,Ritzenthaler Thomas,Rodier Gilles,Rodriguez-Regent Christine,Rodríguez-Yáñez Manuel,Roennefarth Maria,Roffe Christine,Rosenbaum Sverre,Rosso Charlotte,Röther Joachim,Rozanski Michal,Ruiz de Morales Noelia,Russo Francesca,Rutgers Matthieu,Sagnier Sharmilla,Samson Yves,Sánchez Josep,Sauer Tamara,Schäfer Jan H.,Schieber Simon,Schill Josef,Schlak Dennis,Schlemm Ludwig,Schmidt Sein,Schonewille Wouter,Schröder Julian,Schulz Andreas,Schurig Johannes,Schwarting Sönke,Schwarz Alexander,Schwarzbach Christopher,Seidel Matthias,Seiler Alexander,Sembill Jochen,Serena Leal Joaquin,Shetty Ashit,Sibon Igor,Simonsen Claus Z.,Singer Oliver,Sivagnanaratham Aravinth,Smets Ide,Smith Craig,Soors Peter,Sprigg Nikola,Spruegel Maximilian,Stark David,Steinert Susanne,Stösser Sebastian,Stuermlinger Markus,Swinnen Bart,Tamazyan Ruben,Tembl Jose,Terceno Izaga Mikel,Thijs Vincent,Thomalla Götz,Touze Emmanuel,Truelsen Thomas,Turc Guillaume,Turine Gaetane,Tütüncü Serdar,Tyrell Pippa,Ustrell Xavier,Vadot Wilfried,Vallet Anne-Evelyne,Vallet Pauline,van den Berg Lucie,van den Berg Sophie,van Eendenburg Cecile,Van Hooff Robbert-Jan,van Sloten Isabelle,Vanacker Peter,Vancaester Evelien,Vanderdonckt Patrick,Vandermeeren Yves,Vanhee Frederik,Veltkamp Roland,Vestergaard Karsten,Viguier Alain,Vilas Dolores,Villringer Kersten,Voget Dieke,von Schrader Jörg,von Weitzel Paul,Warburton Elisabeth,Weber Claudia,Weber Jörg,Wegscheider Karl,Wegscheider Mirko,Weimar Christian,Weinstich Karin,Weise Christopher,Weise Gesa,Willems Chris,Winder Klemens,Wittayer Matthias,Wolf Marc,Wolf Martin,Wolff Valerie,Wollboldt Christian,Wollenweber Frank,Wouters Anke,Yalo Bertrand,Yger Marion,Younan Nadia,Yperzeele Laetita,Zegarac Vesna,Zeiner Pia,Ziemann Ulf,Zonneveld Thomas,Zuber Mathieu,Akutsu Tsugio,Aoki Junya,Aoki Junya,Arakawa Shuji,Doijiri Ryosuke,Egashira Yusuke,Enomoto Yukiko,Fukuda-Doi Mayumi,Furui Eisuke,Furuta Konosuke,Gotoh Seiji,Hamasaki Toshimitsu,Hasegawa Yasuhiro,Hirano Teryuki,Homma Kazunari,Ichijyo Masahiko,Ide Toshihiro,Igarashi Shuichi,Iguchi Yasuyuki,Ihara Masafumi,Ikenouchi Hajime,Inoue Manabu,Inoue Tsuyoshi,Itabashi Ryo,Ito Yasuhiro,Iwama Toru,Kamiyama Kenji,Kamiyoshi Shoko,Kanai Haruka,Kanematsu Yasuhisa,Kanzawa Takao,Kimura Kazumi,Kitayama Jiro,Kitazono Takanari,Koga Masatoshi,Kondo Rei,Kudo Kohsuke,Kusumi Masayoshi,Kuwahara Ken,Matsumoto Shoji,Matsuoka Hideki,Mihara Ban,Minematsu Kazuo,Miura Ken,Miwa Kaori,Morita Naomi,Mouri Wataru,Murata Kayo,Nagakane Yoshinari,Nakase Taizen,Ohara Hiromi,Ohara Nobuyuki,Ohnishi Hideyuki,Ohta Hajime,Ohtaki Masafumi,Ohtani Ryo,Ohtsuki Toshiho,Ohyama Hideo,Okada Takashi,Okada Yasushi,Osaki Masato,Sakai Nobuyuki,Sanbongi Yoshiki,Sasaki Naoshi,Sasaki Makoto,Sato Shoichiro,Seki Kenta,Shimizu Wataru,Shiokawa Yoshiaki,Sozu Takashi,Suzuki Junichiro,Suzuki Rieko,Takagi Yasushi,Takizawa Shunya,Tanahashi Norio,Tanaka Eijiro,Tanaka Ryota,Tateishi Yohei,Terada Tomoaki,Terasaki Tadashi,Todo Kenichi,Tokunaga Azusa,Toyoda Kazunori,Tsujino Akira,Ueda Toshihiro,Uesaka Yoshikazu,Uotani Mihoko,Urabe Takao,Watanabe Masao,Yagita Yoshiki,Yakushiji Yusuke,Yamamoto Haruko,Yasui Keizo,Yonehara Toshiro,Yoshimura Sohei,Yoshimura Shinichi,Aarnio K.,Alemseged F.,Anderson C.,Ang T.,Archer M.L.,Attia J.,Bailey P.,Balabanski A.,Barber A.,Barber P.A.,Bernhardt J.,Bivard A.,Blacker D.,Bladin C.F.,Brodtmann A.,Cadilhac D.,Campbell B.C.V.,Carey L.,Celestino S.,Chan L.,Chang W.H.,ChangI A.,Chen C.H.,Chen C.-I.,Chen H.F.,Chen T.C.,Chen W.H.,Chen Y.Y.,Cheng C.A.,Cheong E.,Chiou Y.W.,Choi P.M.,Chu H.J.,Chuang C.S.,Chung T.C.,Churilov L.,Clissold B.,Connelly A.,Coote S.,Coulton B.,Cowley E.,Cranefield J.,Curtze S.,D'Este C.,Davis S.M.,Day S.,Desmond P.M.,Dewey H.M.,Ding C.,Donnan G.A.,Drew R.,Eirola S.,Field D.,Frost T.,Garcia-Esperon C.,George K.,Gerraty R.,Grimley R.,Guo Y.C.,Hankey G.,Harvey J.,Ho S.C.,Hogan K.,Howells D.,Hsiao P.M.,Hsu C.H.,Hsu C.T.,Hsu C.-S.,Hsu J.P.,Hsu Y.D.,Hsu Y.T.,Hu C.J.,Huang C.C.,Huang H.Y.,Huang M.Y.,Huang S.C.,Huang W.S.,Jackson D.,Jeng J.S.,Jiang S.K.,Kaauwai L.,Kasari O.,King J.,Kleinig T.J.,Koivu M.,Kolbe J.,Krause M.,Kuan C.W.,Kung W.L.,Kyndt C.,Lau C.L.,Lee A.,Lee C.Y.,Lee J.T.,Lee Y.,Lee Y.C.,Levi C.,Levi C.R.,Lien L.M.,Lim J.C.,Lin C.C.,Lin C.H.,Lin C.M.,Lin D.,Liu C.H.,Liu J.,Lo Y.C.,Loh P.S.,Low E.,Lu C.H.,Lu C.J.,Lu M.K.,Ly J.,Ma H.,Macaulay L.,Macdonnell R.,Mackey E.,Macleod M.,Mahadevan J.,Maxwell V.,McCoy R.,McDonald A.,McModie S.,Meretoja A.,Mishra S.,Mitchell P.J.,Miteff F.,Moore A.,Muller C.,Ng F.,Ng F.C.,Ng J-L.,O'Brian W.,O'Collins V.,Oxley T.J.,Parsons M.W.,Patel S.,Peng G.S.,Pesavento L.,Phan T.,Rodrigues E.,Ross Z.,Sabet A.,Sallaberger M.,Salvaris P.,Shah D.,Sharma G.,Sibolt G.,Simpson M.,Singhal S.,Snow B.,Spratt N.,Stark R.,Sturm J.,Sun M.C.,Sun Y.,Sung P.S.,Sung Y.F.,Suzuki M.,Tan M.,Tang S.C.,Tatlisumak T.,Thijs V.,Tiainen M.,Tsai C.H.,Tsai C.K.,Tsai C.L.,Tsai H.T.,Tsai L.K.,Tseng C.H.,Tseng L.T.,Tsoleridis J.,Tu H.,Tu H.T-H.,Vallat W.,Virta J.,Wang W.C.,Wang Y.T.,Waters M.,Weir L.,Wijeratne T.,Williams C.,Wilson W.,Wong A.A.,Wong K.,Wu T.Y.,Wu Y.H.,Yan B.,Yang F.C.,Yang Y.W.,Yassi N.,Yeh H.L.,Yeh J.H.,Yeh S.J.,Yen C.H.,Young D.,Ysai C.L.,Zhang W.W.,Zhao H.,Zhao L.,Althaus-Knaurer Katharina,Bendszus Martin,Berrouschot Jörg,Bluhmki Erich,Bovi Paolo,Chatellier Gilles,Cove Lynda,Davis Stephen,Dixit A.,Donnan Geoffrey,Dziewas Rainer,Ehrenkrona Christina,Eschenfelder Christoph,Fatar Marc,Francisco Arenillas Juan,Gruber Franz,Hacke Werner,Kala Lalit,Kapeller Peter,Kaste Markku,Kessler Christof,Köhrmann Martin,Laage Rico,Lees Kennedy R.,Leys Didier,Luna Rodriguez Alain,Mas Jean-Louis,Mikulik Robert,Molina Carlos,Muddegowda Girish,Muir Keith,Niederkorn Kurt,Nuñez Xavier,Oppenheim Catherine,Poli Sven,Ringleb Peter,Schellinger Peter,Schwab Stefan,Serena Joaquin,Sobesky Jan,Steiner Thorsten,Svenson Ann-Sofie,Toni Danilo,Veltkamp Roland,von Kummer Rüdiger,Wahlgren Nils,Wardlaw Joanna,Betensky Rebecca A.,Boulouis Gregoire,Carandang Raphael A.,Copen William A.,Cougo Pedro,Cutting Shawna,Drake Kendra,Ford Andria L.,Hallenbeck John,Harris Gordon J.,Hoesch Robert,Hsia Amie,Kase Carlos,Latour Lawrence,Lauer Arne,Lev Michael H.,Muzikansky Alona,Nagaraja Nandakumar,Schwamm Lee H.,Searls Eric,Song Shlee S.,Starkman Sidney,Warach Steven,Wu Ona,Yoo Albert J.,Zand Ramin

Publisher

Elsevier BV

Subject

General Medicine

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