Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial

Author:

Slobogean Gerard P.,Sprague Sheila,Wells Jeffrey L.,Bhandari Mohit,Harris Anthony D.,Mullins C. Daniel,Thabane Lehana,Wood Amber,Della Rocca Gregory J.,Hebden Joan N.,Jeray Kyle J.,Marchand Lucas S.,O'Hara Lyndsay M.,Zura Robert D.,Lee Christopher,Patterson Joseph T.,Gardner Michael J.,Blasman Jenna,Davies Jonah,Liang Stephen,Taljaard Monica,Devereaux PJ,Guyatt Gordon,Heels-Ansdell Diane,Marvel Debra,Palmer Jana E.,Friedrich Jeff,O'Hara Nathan N.,Grissom Frances,Gitajn I. Leah,Morshed Saam,O'Toole Robert V.,Petrisor Bradley,Mossuto Franca,Joshi Manjari G.,D'Alleyrand Jean-Claude G.,Fowler Justin,Rivera Jessica C.,Talbot Max,Pogorzelski David,Dodds Shannon,Li Silvia,Del Fabbro Gina,Szasz Olivia Paige,Bzovsky Sofia,McKay Paula,Minea Alexandra,Murphy Kevin,Howe Andrea L.,Demyanovich Haley K.,Hoskins Wayne,Medeiros Michelle,Polk Genevieve,Kettering Eric,Mahal Nirmen,Eglseder Andrew,Johnson Aaron,Langhammer Christopher,Lebrun Christopher,Nascone Jason,Pensy Raymond,Pollak Andrew,Sciadini Marcus,Degani Yasmin,Phipps Heather,Hempen Eric,Johal Herman,Ristevski Bill,Williams Dale,Denkers Matthew,Rajaratnam Krishan,Al-Asiri Jamal,Gallant Jodi L.,Pusztai Kaitlyn,MacRae Sarah,Renaud Sara,Adams John D.,Beckish Michael L.,Bray Christopher C.,Brown Timothy R.,Cross Andrew W.,Dew Timothy,Faucher Gregory K.,Gurich Jr Richard W.,Lazarus David E.,Millon S. John,Moody M. Christian,Palmer M. Jason,Porter Scott E.,Schaller Thomas M.,Sridhar Michael S.,Sanders John L.,Rudisill Jr L. Edwin,Garitty Michael J.,Poole Andrew S.,Sims Michael L.,Walker Clark M.,Carlisle Robert,Hofer Erin A.,Huggins Brandon,Hunter Michael,Marshall William,Ray Shea B.,Smith Cory,Altman Kyle M.,Pichiotino Erin R.,Quirion Julia C.,Loeffler Markus F.,Cole Austin A.,Maltz Ethan J.,Parker Wesley,Ramsey T. Bennett,Burnikel Alex,Colello Michael,Stewart Russell,Wise Jeremy,Anderson Matthew,Eskew Joshua,Judkins Benjamin,Miller James M.,Tanner Stephanie L.,Snider Rebecca G.,Townsend Christine E.,Pham Kayla H.,Martin Abigail,Robertson Emily,Bray Emily,Sykes J. Wilson,Yoder Krystina,Conner Kelsey,Abbott Harper,Natoli Roman M.,McKinley Todd O.,Virkus Walter W.,Sorkin Anthony T.,Szatkowski Jan P.,Mullis Brian H.,Jang Yohan,Lopas Luke A.,Hill Lauren C.,Fentz Courteney L.,Diaz Maricela M.,Brown Krista,Garst Katelyn M.,Denari Emma W.,Osborn Patrick,Pierrie Sarah N.,Kessler Bradley,Herrera Maria,Miclau Theodore,Marmor Meir T.,Matityahu Amir,McClellan R. Trigg,Shearer David,Toogood Paul,Ding Anthony,Murali Jothi,El Naga Ashraf,Tangtiphaiboontana Jennifer,Belaye Tigist,Berhaneselase Eleni,Pokhvashchev Dmitry,Obremskey William T.,Jahangir Amir Alex,Sethi Manish,Boyce Robert,Stinner Daniel J.,Mitchell Phillip P.,Trochez Karen,Rodriguez Elsa,Pritchett Charles,Hogan Natalie,Fidel Moreno A.,Hagen Jennifer E.,Patrick Matthew,Vlasak Richard,Krupko Thomas,Talerico Michael,Horodyski Marybeth,Pazik Marissa,Lossada-Soto Elizabeth,Gary Joshua L.,Warner Stephen J.,Munz John W.,Choo Andrew M.,Achor Timothy S.,Routt Milton L. “Chip”,Kutzler Michael,Boutte Sterling,Warth Ryan J.,Prayson Michael J.,Venkatarayappa Indresh,Horne Brandon,Jerele Jennifer,Clark Linda,Boulton Christina,Lowe Jason,Ruth John T.,Askam Brad,Seach Andrea,Cruz Alejandro,Featherston Breanna,Carlson Robin,Romero Iliana,Zarif Isaac,Dehghan Niloofar,McKee Michael,Jones Clifford B.,Sietsema Debra L.,Williams Alyse,Dykes Tayler,Guerra-Farfan Ernesto,Tomas-Hernandez Jordi,Teixidor-Serra Jordi,Molero-Garcia Vicente,Selga-Marsa Jordi,Porcel-Vazquez Juan Antonio,Andres-Peiro Jose Vicente,Esteban-Feliu Ignacio,Vidal-Tarrason Nuria,Serracanta Jordi,Nuñez-Camarena Jorge,del Mar Villar-Casares Maria,Mestre-Torres Jaume,Lalueza-Broto Pilar,Moreira-Borim Felipe,Garcia-Sanchez Yaiza,Marcano-Fernández Francesc,Martínez-Carreres Laia,Martí-Garín David,Serrano-Sanz Jorge,Sánchez-Fernández Joel,Sanz-Molero Matsuyama,Carballo Alejandro,Pelfort Xavier,Acerboni-Flores Francesc,Alavedra-Massana Anna,Anglada-Torres Neus,Berenguer Alexandre,Cámara-Cabrera Jaume,Caparros-García Ariadna,Fillat-Gomà Ferran,Fuentes-López Ruben,Garcia-Rodriguez Ramona,Gimeno-Calavia Nuria,Martínez-Álvarez Marta,Martínez-Grau Patricia,Pellejero-García Raúl,Ràfols-Perramon Ona,Peñalver Juan Manuel,Salomó Domènech Mònica,Soler-Cano Albert,Velasco-Barrera Aldo,Yela-Verdú Christian,Bueno-Ruiz Mercedes,Sánchez-Palomino Estrella,Andriola Vito,Molina-Corbacho Matilde,Maldonado-Sotoca Yeray,Gasset-Teixidor Alfons,Blasco-Moreu Jorge,Fernández-Poch Núria,Rodoreda-Puigdemasa Josep,Verdaguer-Figuerola Arnau,Cueva-Sevieri Heber Enrique,Garcia-Gimenez Santiago,Viskontas Darius G.,Apostle Kelly L.,Boyer Dory S.,Moola Farhad O.,Perey Bertrand H.,Stone Trevor B.,Lemke H. Michael,Spicer Ella,Payne Kyrsten,Hymes Robert A.,Schwartzbach Cary C.,Schulman Jeff E.,Malekzadeh A. Stephen,Holzman Michael A.,Gaski Greg E.,Wills Jonathan,Pilson Holly,Carroll Eben A.,Halvorson Jason J.,Babcock Sharon,Goodman J. Brett,Holden Martha B.,Williams Wendy,Hill Taylor,Brotherton Ariel,Romeo Nicholas M.,Vallier Heather A.,Vergon Anna,Higgins Thomas F.,Haller Justin M.,Rothberg David L.,Olsen Zachary M.,McGowan Abby V.,Hill Sophia,Dauk Morgan K.,Bergin Patrick F.,Russell George V.,Graves Matthew L.,Morellato John,McGee Sheketha L.,Bhanat Eldrin L.,Yener Ugur,Khanna Rajinder,Nehete Priyanka,Potter David,VanDemark III Robert,Seabold Kyle,Staudenmier Nicholas,Coe Marcus,Dwyer Kevin,Mullin Devin S.,Chockbengboun Theresa A.,DePalo Sr. Peter A.,Phelps Kevin,Bosse Michael,Karunakar Madhav,Kempton Laurence,Sims Stephen,Hsu Joseph,Seymour Rachel,Churchill Christine,Mayfield Ada,Sweeney Juliette,Jaeblon Todd,Beer Robert,Bauer Brent,Meredith Sean,Talwar Sneh,Domes Christopher M.,Gage Mark J.,Reilly Rachel M.,Paniagua Ariana,Dupree JaNell,Weaver Michael J.,von Keudell Arvind G.,Sagona Abigail E.,Mehta Samir,Donegan Derek,Horan Annamarie,Dooley Mary,Heng Marilyn,Harris Mitchel B.,Lhowe David W.,Esposito John G.,Alnasser Ahmad,Shannon Steven F.,Scott Alesha N.,Clinch Bobbi,Weber Becky,Beltran Michael J.,Archdeacon Michael T.,Sagi Henry Claude,Wyrick John D.,Le Theodore Toan,Laughlin Richard T.,Thomson Cameron G.,Hasselfeld Kimberly,Lin Carol A.,Vrahas Mark S.,Moon Charles N.,Little Milton T.,Marecek Geoffrey S.,Dubuclet Denice M.,Scolaro John A.,Learned James R.,Lim Philip K.,Demas Susan,Amirhekmat Arya,Dela Cruz Yan Marco

Publisher

Elsevier BV

Subject

General Medicine

Reference36 articles.

1. Risk factors for infectious complications after open fractures; a systematic review and meta-analysis;Kortram;Int Orthop,2017

2. Risk factors associated with infection in open fractures of the upper and lower extremities;Tornetta;J Am Acad Orthop Surg Glob Res Rev,2020

3. International Lower Limb Collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures;Berner;Br J Surg,2022

4. Modern external ring fixation versus internal fixation for treatment of severe open tibial fractures: a randomized clinical trial (FIXIT Study);J Bone Joint Surg Am,2022

5. A trial of wound irrigation in the initial management of open fracture wounds;Bhandari;N Engl J Med,2015

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