Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Author:

Parker Chris CORCID,Clarke Noel W,Cook Adrian DORCID,Kynaston HowardORCID,Catton Charles N,Cross William RORCID,Petersen Peter M,Persad Rajendra AORCID,Saad FredORCID,Bower Lorna C,Logue John,Payne HeatherORCID,Forcat Silvia,Goldstein Cindy,Murphy ClaireORCID,Anderson JulietteORCID,Barkati MaroieORCID,Bottomley David MORCID,Branagan Jennifer,Choudhury Ananya,Chung Peter W MORCID,Cogley Lyn,Goh Chee LORCID,Hoskin PeterORCID,Khoo VincentORCID,Malone Shawn CORCID,Masters Lindsey,Morris Stephen L,Nabid AbdenourORCID,Ong Aldrich D,Raman RakeshORCID,Tarver Kathryn L,Tree Alison CORCID,Worlding Jane,Wylie James P,Zarkar Anjali MORCID,Parulekar Wendy RORCID,Parmar Mahesh K BORCID,Sydes Matthew RORCID,Amos Claire,Beaney Katherine,Bellenger Katharine,Brawley Chris,Chung Christina,Cook Adrian,Embleton Andrew,Forcat Silvia,Goldstein Cindy,Grabey Jenna,Hague Dominic,Herasimtschuk Anna,Islam Zaheer,Jovic Gordana,Maniatis Christos,Masters Lindsey,Mohamed Fatima,Morgan Rachel,Murphy Claire,Noor Dipa,Parmar Max,Patterson Paul,Pickering Holly,Pugh Cheryl,Rauchenberger Mary,Ribeiro Helena,Roach Carol,Seray-Wurie Fatimah,Shaji Preetha,Sims Hannah,Spittle Ben,Sydes Matthew,Tappenden Nancy,Tsang Lilian,Uscinska Barbara,Brown Teddy,Casey Sue,Davidson Cathy,Dellar Conor,Fletcher Mandy,Meyer Ralph,Murphy Karen,Parulekar Wendy,Richardson Harriet,Richardson Karen,Whelan Kate,Bissett Donald,Bonner-Shand Shelagh,Grant Judith,Lynch Rory,MacDonald Graham,McWilliam Marie,Moir Rachel,Rodwell Sue,Shearer Kirsty,Smith Margaret,Binns Louise,Briggs Maxine,Brown Simon,Casanova Nathalie,Clark Katy,Hartley Jasmine,Henry Ann,Henson Helen,Hill Pipa,Jeyasanger Ganesan,McAlister Judy,Parkinson Sharron,Shaw Alison,Alcock Christopher,Brady Joanne,Camilleri Philip,Carpenter Janice,Hogbin Emma,Hyde Katherine,Kavanagh Roisin,Ngumo Alice,Padilla-Harris Cheryl,Panakis Niki,Pwint Thinn,Sabharwal Ami,Stammers Tracey,Stone Helena,Varley Gail,Weaver Andrew,Wynn Hazel,Allan Elaine,Ansari Jawaher,Cannon Philip,Carruthers Ross,Coubrough Claudia,Cowan Chloe,Glen Hilary,Graham Janet,Hardie Maryon,Love Clare,Macleod Nicholas,Mahmood Rana,McClements Jane,McGlynn Brian,McKernan Margaret,Mcleod Nick,Othman Aqilah,Ross Kristy,Roxburgh Patricia,Templeton Maureen,Tufail Aisha,Turley Claudia,Wilson Mark,Ali Zulfiqer,Andrews Kelly,Burns Rebecca,Butterworth Caryl,Coventry Thomas,Evans Angela,Jones Gareth,Lewis Sion,Oommen Nikhil,Owen Susan,Saxton Wendy,Tapping Sister Hayley,Thomas Dianne,Thomas Rachel,Walker Beth,Williams Rachel,Collard Susan,Ford Victoria,Goodhind Frances,Holbrook Becky,Kershaw Elizabeth,Ley Samantha,Martinez Maria,McCormack Anne,Sheehan Denise,Toy Elizabeth,Van-Koutrik Lynne,Varughese Mohini,Aitken Katherine,Barlow David,Beattie Louise,Bownie-Mukumbu Godfrey,Bryan Rachel,Corner Victoria,Edwards Abigail,Fazekasne Fulep Adrienn,Guerrero-Urbano Teresa,Gwilt Julie,Happle Liz,Jackman Dee,Krysta Beata,Paisey Sangeeta,Shaffer Richard,Smith Jackie,Westley Rosalyne,Yusof Hilawati,Appleby Rowan,Avis Joanne,Beresford Mark,Brydon-Hill Ruth,Cox Christine,Curtis Samantha,Elwell Christine,Frim Olivera,Hamilton Beatrice,Hudson Zoe,Jenner Abigail,Mantle Mark,Mason Jessica,Masson Susan,McFarlane Jonathan,Newman Hugh,Pocock Abigail,Robertson Bryony,Tomlinson Eve,Wassall Rebecca,Williams (Née Allen) Sister Tania,Brown Grace,Clarke Peter,Cole Aiden,Cousins Jane,Gilchrist Gail,Hagan Chris,Hanna Emma,Harney Jackie,Hetherington Stacey,Houghton Fionnuala,Hynds Sharon,Jain Suneil,Johnston Ruth,Keane Patrick,Lyons Ciara,McAleese Jonathan,McAllister Jo,McKenna Karen,Mitchell Darren,Murray Stacey,O'Sullivan Joe,Rajan Nambi,Shum Poh Lin,Stewart David,Stranex Stephen,Totten Grace,Chandrashekara Madhura,Drew Ellen,Drew Mary (Ellen),Fletcher Julie,Gamble Tina,Lokes Rachel,Schumacher Ann,Shetty Kavitha,Sohanpal Sundip,Whitehouse James,Zarkar Anjali,Ford Daniel,Glaholm John,Lenton Daniel,O'Beney Rachael,Sohanpal Sundip,Taylor Helen,Thomas Helen,Whitehouse James,Chetiyawardana Samantha,Doherty A,El-Modir Ahmed,Ford Daniel,Glaholm John,Gunn Melanie,James Nicholas,Kedge Liz,Lokes Rachel,Mannan Aliyah,Marange Josephine,Morrison Andrew,Okubanjo Maryanne,Olaniyi-Oduntan Darlletta,Peterkin Zhane,Preece George,Qureshi Zayn,Ross Liliam,Samra Tarandip,Southgate Elizabeth,Stephens Rebekah,Stevenson Robert,Watson-Jones Phillip,Zarkar Anjali,Abdulwahid Danya,Ainsworth Sarah,Ashworth Sue,Beard Karen,Charnley Natalie,Desai Parth,Fielding Bethany,Flaherty Jan,Forrest Diane,Frankland Helen,Haidar Imran,Hargreaves Jeanette,Henry Joanne,Hugill Angela,Jewers Karen,Keith Sarah,Kilroy Stephen,King Jennifer,Parikh Omi,Riley Karen,Ryan-Smith Janet,Thomas Jacqueline,Thompson Catherine,Tickle Vivienne,Waring Lynsey,Wise Marcus,Abdulwahid Danya,Ainsworth Sarah,Ashworth Sue,Beard Karen,Dawson Louise,Desai Parth,Ditchfield Julie,Fielding Bethany,Flaherty Jan,Forrest Diane,Frankland Helen,Haidar Imran,Hargreaves Jeanette,Henry Joanne,Hugill Angela,Jewers Karen,Keith Sarah,Kilroy Stephen,King Jennifer,Parikh Omi,Riley Karen,Ryan-Smith Janet,Thompson Catherine,Tickle Vivienne,Waring Lynsey,Wise Marcus,Al-Samarraie Amir,Ali Zulfiqer,Bolger Annette,Davies Llinos,Flavin Aileen,Heron Jane,Hughes Faye,Jackson Kim,Lewis Joanne,Manley Rachel,Oommen Nikhil,Rutter Charley-Anne,Smith Nick,Srinivasan Vaiku,Stockport Jane,Tapping Sister Hayley,Thomas Heather,Toussi H,Wood Cathryn,Archer Simon,Fletcher Joanne,Ginnelly Helen,Kirkby Amy,Knight (n. Sherburn) Victoria,Lawrence nee Palmer Tara,Mashegede Beverley,Metcalf Karen,Panades Miguel,Sreenivasan Thiagarajan,Szymiczek Kinga,Thomas Isobel,Young Anita,Broadley Eve,Brock Sue,Davies Joseph,Jones Stephanie,McCully Ruby,Naraine Nicky,Preece Kate,Purandare Laura,Rabbi Taslima,Savage Sarah,Vamplew Luke,Bamford Linda,Benton Richard,Cotterill Lauren,Henry Ann,Inman Hayley,Karsera Louise,Kay Anne Marie,Kenyon Lucille,Lazarte Jannika,McNulty Dawn,Moore Eleanor,Nallathambi Chandran,Naylor Deirdre,Owen Lisa,Parikh Shefali,Pendrill Amy,Price Joanne,Robertshaw Helen,Rodda Sree,Sewell Jane,Teo Mark,Waldron Eleanor,Bloomfield David,Blythe Tracy,Brown Joanne,Carr Philippa,Chambers Carla,Dlodlo Jessica,Frattaroli Paul,Gilbert Duncan,Hart Andrew,Hodges Samantha,Hooper Simon,Hunter Catherine,Lactao Ranee,Leitao Madalena,McKinna Fiona,Nikapota Ashok,Peterson Jane,Robinson Angus,Tremlett Jean,Webb Andrew,Wilkins Marie,Young Bobbie,Bahl Amit,Baxter Matt,Beresford Mark,Bowers Dawn,Challipalli 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Sanjay,Ramanujachar Ramya,Rimmer Yvonne,Robinson Nicola,Russell Simon,Stone Matthew,Thomas Robert,Treeby Jo,Vickery Kathryn,Woodward Cathryn,Ahmed Ilyas,Appleby Bonny,Brulinski Patryk,Buckley Julie,Catt Natalie,Coppins Helen,Crawford Sister Denise,Davies Julie-Ann,Drakeley Susan,Edwards Albert,Evans Clary,Galante Joao,Gladwell Louise,Gough Jessica,Hargreaves Carolyn,Hegarty Gemma,Kehoe Laura,Larkins Rachel,Lipsham Margaret,Little Jessica,Malde Rohit,Middleton Sharon,Mikropoulos Christos,Mirza Arafat,Mithal Natasha,Nathan Kannon,Raman Rakesh,Rendall Alice,Robinson Karen,Ryan Rachel,Sim Van,Swann Michelle,Tasker Lorraine,Taylor Katy,Thomas Carys,Trigonis Ioannis,Walker Karen,Williams Joanne,Williamson Elizabeth,Wood Marian,Wood Pauline,Zurakovsky Hilary,Bois (nee Harris) Elizabeth,Chan Hin Fan,Chikopela Loveness,Clark Helen,Clements Colette,Holliday Samantha,Hughes Owen,Jones Clare,Kynaston Howard,Mason Malcolm,Narahari Krishna,Pearse Kevin,Staffurth John,Austin Mandy,Barnett Christian,Camburn Sister Tracey,Dawson Elizabeth,Gibson Sian,Hamid Abdel,Kancherla Kiran,Leone Priscilla,Perkins Lauren,Ramsay Valerie,Singizi Bryan,Allen Julie,Anderson Susan,Andrews (nee Moore) Eleanor,Bakawala Rehana,Beazer Sarah,Binks Colin,Bowen Jo,Broomfield Barbara,Cook Audrey,Crossley Lin,Ford Chris,Forkes Janet,Hall Julia,Healey-Mariano Jennifer,Jenkins Peter,Johnson Nigel,Jonnada Sai,Owen Roger,Pratten Elaine,Sayers Rachel,Shimell Chris,Skelton Amy,Tan Matthew,Trigg-Hogarth Kate,Wronski Sue,Aldous Mary,Archer Denise,Eccleson Helen,Gallimore Elizabeth,Green Sue,Ibrahim Azman,Jones Carys,Prince Jude,Chrystal Melanie,Din Omar,Firth Alexandra,Ford Nicky,Kirkbride Peter,Martindale John,Redfearn Alison,Smedley (nee McCabe) Janine,Smith Lucy,Sorice Vittoria,Stevenson Lesley,Toms Julie,Wood Sister Kim,Barke Nyssa,Basu Devy,Dewar Lorna,Driscoll Celine,Hunting Liz,Kumar Muthar,Leone Priscilla,Mabelin Louies,Sizer Bruce,Thorogood Lucy,Askew Sarah,Beech Darren,Broom Jane,Duley Emma,Firth Elizabeth,Gould Aaron,Hocking Christopher,Johns Louise,Kent Emma,Madine John,Partridge Kerena,Penhaligon Corrine,Pentecost Catherine,Pollard Kay,Poultney Melissa,Pynsent William,Skewes Johanna,Steele Anita,Thomson Alastair H,Topps Alice,Townley Luke,Wheatley Duncan,Brown Maggie,Chan Andrew,Connor Marie,Elwell Sue,Geraghty Kerry,Griffiths Theresa,Hayward Lesley,Humber Caroline,Khan Yakhub,Lake Sister Judith,Laverick Rosaleen,Mansell Gemma,Mislang Albert,Ngwenya Su,Panesar Pritpal,Sanders Kay,Simmons Elaine,Sinfield Melanie,Stanley Laura,Steventon Emily,Stockdale Andrew,Sunny Manju,Thind Manreet,Tranter Fiona,Tsalic Medy,Worlding Jane,Adamson Vanessa,Bennion Carole,Butler-Barnes Jenny,Hough Adele,Hough Chris,Hughes Joanne,Irwin P,Javle P,Logue John,Mansfield Carolyn,Smith Rachel,Sumner Lesley,Tomlinson Annabel,Tran Anna,Walker Caroline,Wylie James,Chakraborti Prabir,Das Prantik,Ennis Dawn,Marriott Sue,Muthukumar Dakshinamoorthy,Pattu Pugazhenthi,Ward Colin,Alzouebi Mymoona,Burlace 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David,Etheridge Charlotte,Ford Amanda,Ridley Paul,Scrase Christopher,Upson Susan,Venkitaraman Ramachandran,Capaldi Lisa,Churn Mark,Higgins Linda,Knott Helen,Stringer (pr. Davis) Sally,Taylor Jacob,Tranter Helen,Wollaston Julie,Brogan (nee Roddie) Stephanie,Erskine Susan,Hamill Maureen,Prentice Lynn,Russell Martin,Sidek Norma,Symon Lesley,Teahan Seamus,Todd Anne,Tweedle James,Young Sally,Austin (nee Glover) Gemma,Boon Ian,Bottomley David,Breckin Edmund,Clarke Jude,Coyle Catherine,Davies Emily,Goulding James,Henry Ann,Kiltie Anne,Loughrey Carmel,Moore Eleanor,Murad Fatima,Pratt Claire,Shuttleworth Pam,Smith Beccy,Smith Gill,Branson (née Dineen) Amy,Christmas Sallyanne,Cooke Jill,Griffiths Leyshon,Kent Christopher,King Amy,Kockelbergh Roger,Potterton Janet,Speed Lesley,Vasanthan Subramanian,Walker Julia,Archer Simon,Baria Karin,Bateman Samantha,Coombs Sarah,Cunningham Amy,Dahar Nazeer,Daruwala Pallon,Francis Olesya,Ginnelly Helen,Hall Jane,Hoare Kathryn,Key Claire,Lockwood Carol,Mark Ian,Newton Rachel,Okubanjo Maryanne,Panades Miguel,Sloan Andrew,Sreenivasan Thiagarajan,Bermingham Nicola,Dean Lynsey,Malik Zafar,Pilkington Pauline,Robson Peter,Rogers Heather,Rogers Thomas,Treherne Katy,Bourke Amie,Chikkamuniyappa Bindu,Dalton-Short Ross,Edwards Steve,Falconer Alison,Ford Amy,Harinarayanan Sathish,Hassan Nebah,Hornzee Gillian,Magwaro Sophia,McInerney Sue,Pratap Bhavesh,Rezkallah Sarah,Sadare (Olaleye) Ibiyemi,Stancliffe May,Stewart Simon,Thoi Anne-Maree,Westrop Anna,Ahamadali Sheefa,Arsanious Nasr,Balogun Shaki,Batish Cheryl,Campbell Yvonne,Crowley Claire,Dunne Emma,Ferreira Miguel,Haldeos Anne,Hijab Adham,Huddart Robert,John Babbin,Michaelidou Andriana,Nawrozzadeh Mohammed,Pach Jackie,Patel Priyanka,Payne Ann,Perry Matthew,Sadare (Olaleye) Ibiyemi,Serra Maria,Springall Christine,Thompson Jane,Thomson Sister Jane,Tree Alison,Aya Viviana,Beaney Ronald,Bower Lorna,Conway Lisa-Jane,Donaghey Sally,Gordon Hussain,Grau Isabel,Guerrero-Urbano Teresa,Harris Sarah,Hogan Vesna,Hore Brendan,Hughes Simon,Jones Katie,Kuenzig Greg,Morris Stephen,Nathan Kannon,Nunney Dawn,Rashid Jessica,Reynolds Philip,Rooprai Bali,Chikkamuniyappa 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Lauren,Sathya Jinka R,Teasdale Breanne,Thoms John,Whiteway Chrystal,Whittle Stacy,Cheung Patrick CF,Chu William,Chung Hans T,Commisso Angela,Danjoux Cyril,Escueta Vivette,Klotz Laurence,Leung Michael,Liu Stanley,Loblaw Douglas Andrew,Malek Leila,Morton Gerard,Nam Robert K,Szumacher Ewa,Tseng Eric Chia Lin,Vesprini Danny,Abed Jessy,Ang Daniel,Bayley Andrew J,Berlin Alejandro,Bristow Robert,Catton Charles,Chan Heidi,Chui Amadeus,Chung Peter,Degendorfer Sarah,Gospodarowicz Mary,Gregorcic Emily,Gumapac Nicole,Helou Joelle,Hsien John,Kong Vickie,Lalani Nafisha,Lao Bernadeth,Lawson Daeria,Menard Cynthia,Merante Pat,Milosevic Michael,Mirmooji Ramesh,Muraj Zaynab,Peres Sarin,Petroff Avi,Petrovska Aleksandra,Pineda Sandra,Quintos Judy,Raman Srinivas,Ramotar Sarah,Ruiz Maria Jose Gaitan,Sabate Kathryn,Shukla Arundhati,Tharahan Nanthini,Thevarajah Vaishaali,Tiessen Kyoko,Topalovich Aleksandra,Torres Cynthia,Tse Karen,Tsuji Debbie,Velec Erin,Wallace Kris,Warde Padraig,Bisson MarieEve,Dahmane Rafika,Gagne Vanessa,Harvey Julie,Lebrun Benoit,Marineau Line,Montour Julie,Samson Julie,Sicard MarieEve,Thibeault Andreanne,Vincent Francois,Vincent LindaSuzanne,Blood Paul A,Canavan Joycelin,Clements Mia AnnaMaria,Glick Daniel,Holloway Caroline,Holwerda Eleanor,Joe Howard,Lacey Cathy,Lam Jacqueline,Leong Nelson,Lim Jan,Lomas Alia,Pai Howard H,Priestley Emilie,Shahid Negin,Vallieres Isabelle,Duncan Graeme,Gleave Martin E,Goldenberg S Larry,Karunakaran Subashini,Keyes Mira,KimSing Charmaine,McKenzie Michael,Morris William James,Nakashima Lynne,Peacock Michael,Pickles Thomas A,Rodda Sree,Sibug Sheena,So Alan I,Tyldesley Scott,Zhang Tina Wanting,Ahmed Shahida,Ammeter Barb,Anderson Leanne,Ann Taehee,Bakija Zeljka,Bashir Bashir,Benjaminson Patricia,Bergen Leah,Cadiz Lovely,Chahine Jacqueline,Cherepak Kathy,Chornopyski Tracy,Chowdhury Amitava D,Davies Heather,Dawe David,Drachenberg Darrel E,DuMontier Joelle,Dubey Arbind,Eska Tiffani,Francisco Cristina,Gamez Raquel,Garrett Gina,Giovannini Julia,Graham Jeffrey,Guarino Robyn,Hunter William,Johnston Laurel,Kitkowski Caitlin,Klapp Kathi,Koul Rashmi,Kuzyk Valerie,Last Debbie,Li KuanLin,Long Heather,Majumdar Arpita,Marek Kathleen,McNish Jennifer,Mills Laurie,Morales Maria,Nashed Maged,Nichol Rhonda,Ong Aldrich Dixon,Ouelette Ashley,Patel DeepKumar,Pawl Marilyn,Peak Lisa,Priebe Shauna,Quon Harvey,Rizzuto Stacey,Rudnicki Rayleen,Santos Priscilla,Sharma Atul,Sivananthan Gokulan,Squires Mandy,Trakalo Kathy,Turner Christy,Vaughn Jamie,Walker Lori,Watson Melanie R,Wei Joyce,Weir JoAnn,Woloshyn Rose,Wood Allison,Zhang Hanbo,Zwarych Darlene

Funder

Canadian Cancer Society

Cancer Research Campaign

UKRI Medical Research Council

Publisher

Elsevier BV

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