Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice

Author:

Zhong Wei,Zhang Wenliang,Li Qiong,Xie Guoxiang,Sun Qian,Sun Xiuhua,Tan Xiaobing,Sun Xinguo,Jia Wei,Zhou Zhanxiang

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Hepatology

Reference29 articles.

1. Alcoholic liver disease: pathogenesis and new therapeutic targets;Gao;Gastroenterology,2011

2. Alcohol metabolism;Cederbaum;Clin Liver Dis,2012

3. Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications;Song;J Proteomics,2011

4. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism;Mizoi;Alcohol Alcohol,1994

5. Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages;Isse;Alcohol Clin Exp Res,2005

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