Challenges and issues in bivariate endpoints in study designs of translational medicine

Author:

Zhou QianORCID

Publisher

Elsevier BV

Subject

Hepatology

Reference5 articles.

1. Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma;Chuah;J Hepatol,2022

2. Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?;Ahern;J ImmunoTherapy Cancer,2021

3. Progress and pitfalls in the use of immunotherapy for patients with triple negative breast cancer;Agostinetto;Expert Opin Investig Drugs,2022

4. An escalation for bivariate binary endpoints controlling the risk of overtoxicity (EBE-CRO): managing efficacy and toxicity in early oncology clinical trials;Colin;J Biopharm Stat,2017

5. Balancing risk and benefit in venous thromboembolism trials: concept for a bivariate endpoint trial design and analytic approach;Kittelson;J Thromb Haemost,2013

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