p97 inhibits integrated stress response-induced neuronal apoptosis after subarachnoid hemorrhage in mice by enhancing proteasome function

Author:

Cheng Wenping,Wei Boyang,Liu Wenchao,Jin Lei,Guo Shenquan,Ding Mingxiang,Liu Yanchao,Fan Haiyan,Li Ran,Zhang Xin,He Xuying,Li Xifeng,Duan Chuanzhi

Funder

Guangzhou Municipal Science and Technology Program key projects

National Natural Science Foundation of China

Southern Medical University

Publisher

Elsevier BV

Reference58 articles.

1. Targeting the AAA ATPase p97 as an approach to treat Cancer through disruption of protein homeostasis;Anderson;Cancer Cell,2015

2. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response;Bertolotti;Nat. Cell Biol.,2000

3. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation;Beskow;J. Mol. Biol.,2009

4. Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling;Carrara;Elife,2015

5. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury;Chou;Proc. Natl. Acad. Sci. USA,2017

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