Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

Author:

West Andrew B.ORCID

Funder

NIH

Michael J. Fox Foundation

American Parkinson's Disease Association

Publisher

Elsevier BV

Subject

Developmental Neuroscience,Neurology

Reference61 articles.

1. Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine);Andres-Mateos;J. Neurosci.,2009

2. LRRK2 kinase inhibitors of different structural classes induce abnormal accumulation of lamellar bodies in type II pneumocytes in non-human primates but are reversible and without pulmonary functional consequences;Baptista,2015

3. Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs;Baptista;PLoS One,2013

4. LRRK2 contributes to monocyte dysregulation in Parkinson's disease;Bliederhaeuser;Acta Neuropathol. Commun.,2016

5. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury;Boddu;Hum. Mol. Genet.,2015

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