Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

Author:

Matthew Elizabeth M.,Yang Zhaohai,Peri Suraj,Andrake MarkORCID,Dunbrack Roland,Ross Eric,El-Deiry Wafik S.

Publisher

Elsevier BV

Subject

Cancer Research

Reference58 articles.

1. Defining the role of mTOR in cancer;Guertin;Cancer Cell,2007

2. The tuberous sclerosis complex;Crino;N Engl J Med,2006

3. Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner;Astrinidis;Hum Mol Genet,2006

4. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions;Matthew;Cell Cycle,2009

5. Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells;Burns;Mol Cell Biol,2003

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