Preliminary results of the application of a silk fibroin scaffold to otology

Author:

Levin Brett1,Redmond Sharon Leanne2,Rajkhowa Rangam2,Eikelboom Robert Henry2,Marano Robert Jeffery2,Atlas Marcus David2

Affiliation:

1. From the Ear Science Institute of Australia and Ear Sciences Centre, School of Surgery, The University of Western Australia (Drs. Levin, Eikelboom, and Marano, Ms. Redmond, and Mr. Atlas), Sir Charles Gairdner Hospital (Dr. Levin and Mr. Atlas), St. John of God Hospital (Mr. Atlas), Perth, Western Australia, Australia; and the Centre for Material and Fibre Innovation, Deakin University (Mr. Rajkhowa), Geelong, Victoria, Australia.  blevin@med.usyd.edu.au

2. From the Ear Science Institute of Australia and Ear Sciences Centre, School of Surgery, The University of Western Australia (Drs. Levin, Eikelboom, and Marano, Ms. Redmond, and Mr. Atlas), Sir Charles Gairdner Hospital (Dr. Levin and Mr. Atlas), St. John of God Hospital (Mr. Atlas), Perth, Western Australia, Australia; and the Centre for Material and Fibre Innovation, Deakin University (Mr. Rajkhowa), Geelong, Victoria, Australia.

Abstract

The surgical treatment to repair chronic tympanic membrane perforations is myringoplasty. Although multiple autologous grafts, allografts, and synthetic graft materials have been used over the years, no single graft material is superior for repairing all perforation types. Recently, the remarkable properties of silk fibroin protein have been studied, with biomedical and tissue engineering applications in mind, across a number of medical and surgical disciplines. The present study examines the use of silk fibroin for its potential suitability as an alternative graft in myringoplasty surgery by investigating the growth and proliferation of human tympanic membrane keratinocytes on a silk fibroin scaffold in vitro. Light microscopy, immunofluorescent staining, and confocal imaging all reveal promising preliminary results. The biocompatibility, transparency, stability, high tensile strength, and biodegradability of fibroin make this biomaterial an attractive option to study for this utility.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

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