Clopidogrel (Plavix) reduces the rate of thrombosis in the rat tuck model for microvenous anastomosis

Abstract

Objective To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure. Study Design and Setting Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous “tuck” procedure was performed. The bleeding time and vessel patency were subsequently evaluated. Results The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 ± 100 seconds vs 173 ± 59 seconds, P < 0.015). Conclusion Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure. Significance The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.