Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats-Reference-Cited by-同舟云学术

Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats

Published:2009-05 Issue:5 Volume:140 Page:720-723
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Ertuğrul Eylem Ertug¹,Çekin İ. Engin²,Cincik Hakan²,Doğru Salim²,Güngör Atila²

Affiliation:

1. ENT Department, Güneydoğu Medical Center, Diyarbakir, Turkey

2. ENT Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Abstract

Objective: The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury. Materials and Methods: After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis. Results: The fibrosis indexes of the treated group were significantly less than those of the control group ( P < 0.05). Conclusions: Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2008.12.050

Reference18 articles.

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2. Endoscopic Treatment of Subglottic and Tracheal Stenosis by Radial Laser Incision and Dilation

3. The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study)

4. Halofuginone: A Novel Antifibrotic Therapy

5. Halofuginone-an Inhibitor of Collagen Type I Synthesis-Prevents Postoperative Formation of Abdominal Adhesions

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