Propofol-induced sleep: Polysomnographic evaluation of patients with obstructive sleep apnea and controls

Author:

Rabelo Fábio A.W.1,Braga Adriano1,Küpper Daniel S.1,De Oliveira José A.A.1,Lopes Fernando M.2,de Lima Mattos Pedro Luiz Vaz2,Barreto Shirley G.3,Sander Heidi H.3,Fernandes Regina M.F.3,Valera Fabiana C.P.1

Affiliation:

1. Discipline of Otorhinolaryngology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

2. Discipline of Anesthesiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

3. Department of Neuroscience and Sciences of Behavior, Division of Neurology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

Abstract

Objective: The localization of upper airway obstruction in patients with obstructive sleep apnea (OSA) may optimize treatment. Nasoendoscopy during propofol sedation allows such an evaluation, but the effect of this drug on respiratory patterns and muscle relaxation is unknown. The objective of the present study was to determine through polysomnography whether propofol would change sleep parameters. Study Design: Prospective study of subjects submitted to polysomnography under sedation with propofol. Setting: Tertiary referral center. Subjects and Methods: Fifteen non-obese subjects (4 controls/11 OSA patients) were submitted to two diurnal polysomnograms (90-120 minutes of sleep), with and without the use of propofol. The parameters presence of snoring, apnea-hypopnea index (AHI), oxygen desaturation, and sleep architecture were compared. Results: The use of propofol did not induce snoring in the control subjects, whereas 100 percent of the OSA patients snored. AHI and mean oxygen saturation (SaO2) did not differ significantly between examinations with and without sedation. However, minimum SaO2 differed significantly ( P < 0.05) with sedation, being lower during propofol sedation. Propofol also significantly changed the sleep architecture, with a significant increase in N3 sleep ( P < 0.005) and total abolishment of rapid eye movement sleep ( P < 0.0005) during propofol sedation. Conclusions: These preliminary results allow us to infer that sedation with propofol changes sleep architecture but permits respiratory evaluation, because the main respiratory parameters evaluated in OSA are maintained. These preliminary results support the view that nasoendoscopy under propofol sedation is a promising examination for management of this disease.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Cited by 121 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3