Benefits and risks of mitomycin use in the traumatized tracheal mucosa

Author:

Roh Jong-Lyel1,Kim Dong Hyun2,Rha Ki Sang2,Sung Myung-Whun3,Kim Kwang Hyun3,Park Chan II2

Affiliation:

1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine Seoul, South Korea

2. Department of Otolaryngology-Head and Neck Surgery and Cancer Research Institute, Chungnam National University College of Medicine, Daejeon Seoul, South Korea

3. Department of Otolaryngology-Head and Neck Surgery and Cancer Research Institute, Seoul National University College of Medicine Seoul, South Korea

Abstract

Objective To investigate the efficacy and early complications of mitomycin C (MMC) in tracheal wound models. Study Design and Setting Rabbits (N = 60) were randomized to undergo mucosal injuries to the upper and lower trachea including anterior 120° full thickness (group A, n = 20), anterior 120° partial thickness (group B, 20), and circumferential partial thickness (group C, 20). In each rabbit, the wounds were separately treated with MMC 1.0 mg/mL or saline, and the animals were sacrificed after three weeks. Results Twenty-seven of the 60 animals experienced early death because of tracheal rupture or airway obstruction caused by unresolved scabs on the preinjured tracheal mucosa; the incidence of early death was higher in groups A and C than in group B. In each group, the degree of tracheal stenosis was comparable in wounds treated with MMC and saline. Conclusion These findings suggest that topical MMC has no benefit when used to prevent tracheal stenosis. Acute airway obstruction may occur in MMC-treated rabbits with tracheal wounds.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

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