The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis-Reference-Cited by-同舟云学术

The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis

Published:2008-08 Issue:2 Volume:139 Page:211-215
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Can Ilknur Haberal¹,Ceylan Kursat¹,Caydere Muzaffer²,Samim Ethem Erdal¹,Ustun Huseyin²,Karasoy Durdu Sertkaya³

Affiliation:

1. The ENT Clinic, Ankara, Turkey

2. Department of athology Clinic, Ministry of Health Ankara Education and Training Hospital, Ankara, Turkey

3. Department of Statistics, Hacettepe University, Ankara, Turkey

Abstract

OBJECTIVES: To investigate the expression and clinical significance of MMP-2, MMP-7, MMP-9, and TIMP-1 in patients with nasal polyposis (NP) and chronic rhinosinusitis (CRS). STUDY DESIGN: Prospective study. SUBJECTS AND METHODS: This study involved 54 patients. There were three groups: nasal polyposis group, chronic rhinosinusitis group, and control group. Specimens were collected during endoscopic sinus surgery. Each sample was immunohistochemically examined. RESULTS: Expression of MMP-2 was found significantly increased in NP, whereas MMP-7 expression was found significantly increased in CRS ( P < 0.001). TIMP-1 was significantly high in control group compared to CRS and NP ( P < 0.001 and P = 0.002, respectively). CONCLUSIONS: Different regulation type of activation of MMPs has been found in these two diseases. If MMP-2 expression is intense in the mucosa, then this ends with polyp formation; if MMP-7 expression is intense, it ends with CRS or stays as CRS.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2008.04.032

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