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The in vivo dermal absorption and metabolism of [4-14C]coumarin by rats and by human volunteers under simulated conditions of use in fragrances

  • Published:2001-02 Issue:2 Volume:39 Page:153-162
  • ISSN:0278-6915
  • Container-title:Food and Chemical Toxicology
  • language:en
  • Short-container-title:Food and Chemical Toxicology

Author:

Ford R.A,Hawkins D.R,Mayo B.C,Api A.M

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

Reference32 articles.

1. Common Fragrance and Flavor Materials;Bauer,1990

2. Comparative in vitro skin absorption and metabolism of coumarin (1,2-benzopyrone) in human, rat, and mouse;Beckley-Kartey;Toxicology and Applied Pharmacology,1997

3. Synthesis and reactivity of coumarin 3, 4-epoxide;Born;Drug Metabolism and Disposition,1997

4. Selective Clara cell injury in mouse lung following acute administration of coumarin;Born;Toxicology and Applied Pharmacology,1998

5. o-Hydroxyphenylacetaldehyde (o-HPA) is a hepatotoxic metabolite of coumarin;Born;Toxicological Sciences,1998
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