Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study

Author:

De Santis Olga,Audran Régine,Pothin Emilie,Warpelin-Decrausaz Loane,Vallotton Laure,Wuerzner Grégoire,Cochet Camille,Estoppey Daniel,Steiner-Monard Viviane,Lonchampt Sophie,Thierry Anne-Christine,Mayor Carole,Bailer Robert T,Mbaya Olivier Tshiani,Zhou Yan,Ploquin Aurélie,Sullivan Nancy J,Graham Barney S,Roman François,De Ryck Iris,Ballou W Ripley,Kieny Marie Paule,Moorthy Vasee,Spertini François,Genton Blaise

Publisher

Elsevier BV

Subject

Infectious Diseases

Reference19 articles.

1. Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge;Stanley;Nat Med,2014

2. A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults;Ledgerwood;Vaccine,2010

3. Chimpanzee adenovirus vector Ebola vaccine—preliminary report;Ledgerwood;N Engl J Med,2014

4. Phase 1 trials of rVSV Ebola vaccine in Africa and Europe—preliminary report;Agnandji;N Engl J Med,2015

5. Recombinant adenovirus serotype 26 (Ad26) and Ad35 vaccine vectors bypass immunity to ad5 and protect nonhuman primates against Ebolavirus challenge;Geisbert;J Virol,2011

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